This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Histone methyltransferase
From Proteopedia
| Line 22: | Line 22: | ||
**[[3s8s]] – hKHMT SETD1A RRM domain<br /> | **[[3s8s]] – hKHMT SETD1A RRM domain<br /> | ||
| + | **[[2mdc]], [[2mdj]] - hKHMT SETD2 WW domain - NMR<br /> | ||
| + | **[[2mdi]] - hKHMT SETD2 WW domain (mutant) - NMR<br /> | ||
**[[2r3a]] – hKHMT Suv39H2<br /> | **[[2r3a]] – hKHMT Suv39H2<br /> | ||
**[[3rq4]] - hKHMT Suv420H2<br /> | **[[3rq4]] - hKHMT Suv420H2<br /> | ||
| Line 31: | Line 33: | ||
**[[2kyu]] - hKHMT Mll Phd3 finger – NMR<br /> | **[[2kyu]] - hKHMT Mll Phd3 finger – NMR<br /> | ||
**[[4gnd]] - hKHMT Nsd3 Phd5-C5HCH<br /> | **[[4gnd]] - hKHMT Nsd3 Phd5-C5HCH<br /> | ||
| + | **[[4rxj]] - hKHMT Nsd3 residues 953-1064<br /> | ||
| + | **[[4yz8]] - hKHMT Nsd3 residues 1054-1285<br /> | ||
**[[3lqh]] - hKHMT Mll Phd bromodomain<br /> | **[[3lqh]] - hKHMT Mll Phd bromodomain<br /> | ||
**[[3b7b]] - hKHMT ankyrin repeat domains 2-7<br /> | **[[3b7b]] - hKHMT ankyrin repeat domains 2-7<br /> | ||
| Line 70: | Line 74: | ||
**[[3rib]] – hKHMT Smyd2 + SAH<br /> | **[[3rib]] – hKHMT Smyd2 + SAH<br /> | ||
**[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | **[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | ||
| + | **[[4wuy]] - hKHMT Smyd2 + inhibitor<br /> | ||
**[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br /> | **[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br /> | ||
**[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br /> | **[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br /> | ||
| Line 108: | Line 113: | ||
**[[2v74]], [[2v7e]] – mRHMT catalytic domain <br /> | **[[2v74]], [[2v7e]] – mRHMT catalytic domain <br /> | ||
| + | **[[4c03]], [[4c06]], [[4c07]], [[4c08]] – mRHMT 6<br /> | ||
| + | **[[4c04]] – mRHMT 6 + inhibitor<br /> | ||
| + | **[[4c05]] – mRHMT 6 + SAH<br /> | ||
| + | **[[4c4a]] – mRHMT 7 + SAH<br /> | ||
**[[2obq]] – rRHMT N terminal - rat <br /> | **[[2obq]] – rRHMT N terminal - rat <br /> | ||
**[[3b3g]], [[3b3j]] – rRHMT catalytic domain <br /> | **[[3b3g]], [[3b3j]] – rRHMT catalytic domain <br /> | ||
**[[3b3f]] – rRHMT catalytic domain + SAH<br /> | **[[3b3f]] – rRHMT catalytic domain + SAH<br /> | ||
| - | **[[2y1w]], [[2y1x]] – hRHMT catalytic domain + sinefungin + indole inhibitor<br /> | + | **[[2y1w]], [[2y1x]] – hRHMT 4 catalytic domain + sinefungin + indole inhibitor<br /> |
| - | **[[4ikp]] – hRHMT catalytic domain + purine derivative<br /> | + | **[[4ikp]] – hRHMT 4 catalytic domain + purine derivative<br /> |
| + | **[[4gqb]] – hRHMT 5 + methylsome protein 50 + H4 peptide<br /> | ||
| + | **[[4qqk]] – hRHMT 6 <br /> | ||
| + | **[[4hc4]] – hRHMT 6 (mutant)<br /> | ||
| + | **[[4qpp]] – hRHMT 6 (mutant) + peptide + inhibitor<br /> | ||
| + | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:11, 21 April 2015
Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain.
3D Structures of histone methyltransferase
Updated on 21-April-2015
