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1pmq
From Proteopedia
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| - | {{STRUCTURE_1pmq| PDB=1pmq | SCENE= }}
| + | #REDIRECT [[4z9l]] This PDB entry is obsolete and replaced by 4z9l |
| - | ===The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor===
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| - | {{ABSTRACT_PUBMED_12954329}}
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| - | ==Disease==
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| - | [[http://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[http://omim.org/entry/606369 606369]]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. | + | |
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref>
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| - | ==About this Structure==
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| - | [[1pmq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMQ OCA].
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| - | ==See Also==
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| - | *[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]]
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| - | ==Reference==
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| - | <ref group="xtra">PMID:012954329</ref><references group="xtra"/><references/>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Mitogen-activated protein kinase]]
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| - | [[Category: Becker, J W.]]
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| - | [[Category: Lisnock, J.]]
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| - | [[Category: LoGrasso, P V.]]
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| - | [[Category: Patel, S B.]]
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| - | [[Category: Scapin, G.]]
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| - | [[Category: Apoptosis]]
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| - | [[Category: Inhibition]]
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| - | [[Category: Map kinase]]
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| - | [[Category: Transferase]]
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Current revision
- REDIRECT 4z9l This PDB entry is obsolete and replaced by 4z9l
