Plasminogen
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
{{STRUCTURE_1qrz| PDB=1qrz | SIZE=400| SCENE= |right|CAPTION=Human plasmin catalytic domain tetramer, [[1qrz]] }} | {{STRUCTURE_1qrz| PDB=1qrz | SIZE=400| SCENE= |right|CAPTION=Human plasmin catalytic domain tetramer, [[1qrz]] }} | ||
| - | '''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. | + | '''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. The kringle domain folds into a large loop containing 3 disulfide bonds. The kringle domain is important in protein-protein interaction with blood coagulation factors. |
== 3D Structures of plasminogen == | == 3D Structures of plasminogen == | ||
| Line 17: | Line 17: | ||
**[[1cea]] - hPLG kringle 1 + e-aminocaprioic acid<BR /> | **[[1cea]] - hPLG kringle 1 + e-aminocaprioic acid<BR /> | ||
**[[1hpj]], [[1hpk]] - hPLG kringle 1 + 6-aminohexanoic acid - NMR<BR /> | **[[1hpj]], [[1hpk]] - hPLG kringle 1 + 6-aminohexanoic acid - NMR<BR /> | ||
| - | **[[1ceb]] - hPLG kringle 1 + AMCHA | + | **[[1ceb]] - hPLG kringle 1 + AMCHA<br /> |
| + | **[[4cik]] - hPLG kringle 1 + inhibitor<br /> | ||
*Plasminogen kringle 2 | *Plasminogen kringle 2 | ||
Revision as of 10:55, 13 May 2015
Plasmin (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. The kringle domain folds into a large loop containing 3 disulfide bonds. The kringle domain is important in protein-protein interaction with blood coagulation factors.
3D Structures of plasminogen
Updated on 13-May-2015
