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4ra2
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==PP2Ca== |
| - | + | <StructureSection load='4ra2' size='340' side='right' caption='[[4ra2]], [[Resolution|resolution]] 1.94Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ra2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RA2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ra2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ra2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ra2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ra2 PDBsum]</span></td></tr> | |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | [ | + | [[http://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN]] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref> |
| - | [ | + | == References == |
| - | [ | + | <references/> |
| - | [[ | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Phosphoprotein phosphatase]] |
| - | [[Category: | + | [[Category: Liu, H D]] |
| + | [[Category: Meng, F G]] | ||
[[Category: Pan, C]] | [[Category: Pan, C]] | ||
| - | [[Category: Wang, W | + | [[Category: Sun, J P]] |
| + | [[Category: Tang, J Y]] | ||
| + | [[Category: Wang, H A]] | ||
| + | [[Category: Wang, W B]] | ||
| + | [[Category: Xiao, P]] | ||
| + | [[Category: Xu, Y F]] | ||
| + | [[Category: Yu, X]] | ||
| + | [[Category: Metal binding protein]] | ||
| + | [[Category: Phosphorylation]] | ||
| + | [[Category: Pp2c family]] | ||
| + | [[Category: Serine/threonine phosphatase]] | ||
Revision as of 12:22, 13 May 2015
PP2Ca
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