2z9g

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[[Image:2z9g.jpg|left|200px]]<br /><applet load="2z9g" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2z9g.jpg|left|200px]]
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caption="2z9g, resolution 1.86&Aring;" />
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'''Complex structure of SARS-CoV 3C-like protease with PMA'''<br />
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{{Structure
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|PDB= 2z9g |SIZE=350|CAPTION= <scene name='initialview01'>2z9g</scene>, resolution 1.86&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene> and <scene name='pdbligand=BNZ:BENZENE'>BNZ</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Complex structure of SARS-CoV 3C-like protease with PMA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2Z9G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus] with <scene name='pdbligand=HG:'>HG</scene> and <scene name='pdbligand=BNZ:'>BNZ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9G OCA].
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2Z9G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9G OCA].
==Reference==
==Reference==
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Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17981158 17981158]
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Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17981158 17981158]
[[Category: Sars coronavirus]]
[[Category: Sars coronavirus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc-finger]]
[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:00:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:53:05 2008''

Revision as of 16:53, 20 March 2008

Image:2z9g.jpg


PDB ID 2z9g

Drag the structure with the mouse to rotate
, resolution 1.86Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Complex structure of SARS-CoV 3C-like protease with PMA


Overview

Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.

About this Structure

2Z9G is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:17981158

Page seeded by OCA on Thu Mar 20 18:53:05 2008

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