362d

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[[Image:362d.gif|left|200px]]<br /><applet load="362d" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:362d.gif|left|200px]]
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caption="362d, resolution 1.300&Aring;" />
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'''THE STRUCTURE OF D(TGCGCA)2 AND A COMPARISON TO OTHER Z-DNA HEXAMERS'''<br />
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{{Structure
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|PDB= 362d |SIZE=350|CAPTION= <scene name='initialview01'>362d</scene>, resolution 1.300&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NCO:COBALT HEXAMMINE ION'>NCO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''THE STRUCTURE OF D(TGCGCA)2 AND A COMPARISON TO OTHER Z-DNA HEXAMERS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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362D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NCO:'>NCO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. This structure supersedes the now removed PDB entry 347D. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=362D OCA].
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362D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. This structure supersedes the now removed PDB entry 347D. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=362D OCA].
==Reference==
==Reference==
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Structure of d(TGCGCA)2 and a comparison to other DNA hexamers., Harper A, Brannigan JA, Buck M, Hewitt L, Lewis RJ, Moore MH, Schneider B, Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1273-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10089504 10089504]
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Structure of d(TGCGCA)2 and a comparison to other DNA hexamers., Harper A, Brannigan JA, Buck M, Hewitt L, Lewis RJ, Moore MH, Schneider B, Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1273-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10089504 10089504]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Brannigan, J A.]]
[[Category: Brannigan, J A.]]
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[[Category: z-dna]]
[[Category: z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:54:58 2008''

Revision as of 16:55, 20 March 2008

Image:362d.gif


PDB ID 362d

Drag the structure with the mouse to rotate
, resolution 1.300Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



THE STRUCTURE OF D(TGCGCA)2 AND A COMPARISON TO OTHER Z-DNA HEXAMERS


Overview

The X-ray crystal structure of d(TGCGCA)2 has been determined at 120 K to a resolution of 1.3 A. Hexamer duplexes, in the Z-DNA conformation, pack in an arrangement similar to the 'pure spermine form' [Egli et al. (1991). Biochemistry, 30, 11388-11402] but with significantly different cell dimensions. The phosphate backbone exists in two equally populated discrete conformations at one nucleotide step, around phosphate 11. The structure contains two ordered cobalt hexammine molecules which have roles in stabilization of both the Z-DNA conformation of the duplex and in crystal packing. A comparison of d(TGCGCA)2 with other Z-DNA hexamer structures available in the Nucleic Acid Database illustrates the elusive nature of crystal packing. A review of the interactions with the metal cations Na+, Mg2+ and Co3+ reveals a relatively small proportion of phosphate binding and that close contacts between metal ions are common. A prediction of the water structure is compared with the observed pattern in the reported structure.

About this Structure

362D is a Protein complex structure of sequences from [1]. This structure supersedes the now removed PDB entry 347D. Full crystallographic information is available from OCA.

Reference

Structure of d(TGCGCA)2 and a comparison to other DNA hexamers., Harper A, Brannigan JA, Buck M, Hewitt L, Lewis RJ, Moore MH, Schneider B, Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1273-84. PMID:10089504

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