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4z36
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-3080573== |
| - | + | <StructureSection load='4z36' size='340' side='right' caption='[[4z36]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4z36]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z36 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=ON3:1-(4-{[(2S,3R)-2-(2,3-DIHYDRO-1H-INDEN-2-YLOXY)-3-(3,5-DIMETHOXY-4-METHYLPHENYL)-3-HYDROXYPROPYL]OXY}PHENYL)CYCLOPROPANECARBOXYLIC+ACID'>ON3</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4z34|4z34]], [[4z35|4z35]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4z36 RCSB], [http://www.ebi.ac.uk/pdbsum/4z36 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | + | == Function == | |
| - | + | [[http://www.uniprot.org/uniprot/LPAR1_HUMAN LPAR1_HUMAN]] Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.<ref>PMID:19306925</ref> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Asmar-Rovira, G]] | ||
| + | [[Category: Chrencik, J E]] | ||
[[Category: Chun, J]] | [[Category: Chun, J]] | ||
| + | [[Category: GPCR, GPCR Network]] | ||
| + | [[Category: Griffith, M T]] | ||
| + | [[Category: Han, G W]] | ||
| + | [[Category: Hanson, M A]] | ||
| + | [[Category: Kihara, Y]] | ||
[[Category: Kurata, H]] | [[Category: Kurata, H]] | ||
| - | [[Category: | + | [[Category: Mileni, M]] |
| + | [[Category: Mizuno, H]] | ||
| + | [[Category: Nakade, S]] | ||
[[Category: Omi, R]] | [[Category: Omi, R]] | ||
| - | [[Category: | + | [[Category: Rodgers, C]] |
| - | [[Category: | + | [[Category: Roth, C B]] |
| - | [[Category: | + | [[Category: Stevens, R C]] |
| - | [[Category: | + | [[Category: Terakado, M]] |
[[Category: Velasquez, J]] | [[Category: Velasquez, J]] | ||
| - | [[Category: | + | [[Category: Warshaviak, D]] |
| - | [[Category: Gpcr | + | [[Category: Antagonist]] |
| - | [[Category: | + | [[Category: Compound design]] |
| - | [[Category: | + | [[Category: Endogenous ligand]] |
| + | [[Category: Gpcr network]] | ||
| + | [[Category: Lipid receptor]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Novel disulfide bond engineering]] | ||
| + | [[Category: Polypharmacology]] | ||
| + | [[Category: Psi-biology]] | ||
| + | [[Category: Structural genomic]] | ||
Revision as of 12:48, 3 June 2015
Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-3080573
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Categories: Asmar-Rovira, G | Chrencik, J E | Chun, J | GPCR, GPCR Network | Griffith, M T | Han, G W | Hanson, M A | Kihara, Y | Kurata, H | Mileni, M | Mizuno, H | Nakade, S | Omi, R | Rodgers, C | Roth, C B | Stevens, R C | Terakado, M | Velasquez, J | Warshaviak, D | Antagonist | Compound design | Endogenous ligand | Gpcr network | Lipid receptor | Membrane protein | Novel disulfide bond engineering | Polypharmacology | Psi-biology | Structural genomic
