4xfx
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structure of the native full-length HIV-1 capsid protein== |
| - | + | <StructureSection load='4xfx' size='340' side='right' caption='[[4xfx]], [[Resolution|resolution]] 2.43Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4xfx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xfy|4xfy]], [[4xfz|4xfz]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xfx RCSB], [http://www.ebi.ac.uk/pdbsum/4xfx PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Sarafianos, S | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Gres, A T]] | ||
| + | [[Category: Kirby, K A]] | ||
| + | [[Category: Sarafianos, S G]] | ||
| + | [[Category: Capsid protein]] | ||
| + | [[Category: Native]] | ||
Revision as of 14:09, 10 June 2015
Structure of the native full-length HIV-1 capsid protein
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