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**[[2a1k]] – SSB gp32 – Enterobacteria phage RB69 <br /> | **[[2a1k]] – SSB gp32 – Enterobacteria phage RB69 <br /> | ||
**[[1je5]] – SSB – Enterobacteria phage T7 <br /> | **[[1je5]] – SSB – Enterobacteria phage T7 <br /> | ||
| - | **[[1adu]], [[1adv]], [[1anv]] – SSB C terminal – human adenovirus 5 <br /> | + | **[[1adu]], [[1adv]], [[1anv]], [[2waz]], [[2wb0]] – SSB C terminal – human adenovirus 5 <br /> |
**[[1urj]] – SSB – human herpesvirus 1 <br /> | **[[1urj]] – SSB – human herpesvirus 1 <br /> | ||
**[[1pfs]] – SSB (mutant) – Pseudomonas phage PF3 - NMR<br /> | **[[1pfs]] – SSB (mutant) – Pseudomonas phage PF3 - NMR<br /> | ||
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**[[1kaw]] – EcSSB chymotryptic domain – ''Escherichia coli'' <br /> | **[[1kaw]] – EcSSB chymotryptic domain – ''Escherichia coli'' <br /> | ||
**[[1qvc]], [[1sru]] – EcSSB <br /> | **[[1qvc]], [[1sru]] – EcSSB <br /> | ||
| - | **[[1o7i]] – | + | **[[1o7i]] – SsSSB residues 1-119 – ''Sulfolobus solfataricus''<br /> |
**[[1ue1]], [[1ue5]], [[1ue7]], [[1ue6]] – SSB – ''Mycobacterium tuberculosis'' <br /> | **[[1ue1]], [[1ue5]], [[1ue7]], [[1ue6]] – SSB – ''Mycobacterium tuberculosis'' <br /> | ||
**[[1x3e]], [[1x3f]], [[1x3g]] – MsSSB – ''Mycobacterium smegmatis'' <br /> | **[[1x3e]], [[1x3f]], [[1x3g]] – MsSSB – ''Mycobacterium smegmatis'' <br /> | ||
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**[[3a5u]] – MsSSB chymotryptic domain + ssDNA <br /> | **[[3a5u]] – MsSSB chymotryptic domain + ssDNA <br /> | ||
**[[3udg]] – DrSSB + ssDNA <br /> | **[[3udg]] – DrSSB + ssDNA <br /> | ||
| + | **[[2mna]] – SsSSB + ssDNA - NMR<br /> | ||
*Other single-stranded DNA-binding protein complexes | *Other single-stranded DNA-binding protein complexes | ||
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**[[2b3g]] - hRPA70 N terminal + p53 peptide<br /> | **[[2b3g]] - hRPA70 N terminal + p53 peptide<br /> | ||
**[[4nb3]] - hRPA70 N terminal (mutant) + peptide<br /> | **[[4nb3]] - hRPA70 N terminal (mutant) + peptide<br /> | ||
| - | **[[4ijh]], [[4ijl]], [[4iph]], [[4luo]], [[4luv]], [[4luz]], [[4lw1]], [[4lwc]], [[4o0a]] - hRPA70 N terminal (mutant) + inhibitor<br /> | + | **[[4ijh]], [[4ijl]], [[4iph]], [[4luo]], [[4luv]], [[4luz]], [[4lw1]], [[4lwc]], [[4o0a]], [[4r4c]], [[4r4i]], [[4r4o]], [[4r4q]], [[4r4t]] - hRPA70 N terminal (mutant) + inhibitor<br /> |
*Replication protein A70+A14+A32 | *Replication protein A70+A14+A32 | ||
Revision as of 09:46, 16 June 2015
Single-stranded DNA-binding protein (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities. Viral SSB proteins are monomeric while eukaryotic SSB (Replication protein A – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14. RPA has 6 DNA-binding domains (DBD). The mitochondrial human SSB (HsmtSSB) is a homotetramer. See also Single stranded binding protein.
3D Structures of single-stranded DNA-binding protein
Updated on 16-June-2015