This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3byz
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:3byz.jpg|left|200px]] | + | [[Image:3byz.jpg|left|200px]] |
| - | + | ||
| - | '''2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors''' | + | {{Structure |
| + | |PDB= 3byz |SIZE=350|CAPTION= <scene name='initialview01'>3byz</scene>, resolution 2.69Å | ||
| + | |SITE= <scene name='pdbsite=AC1:Ndp+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Ndp+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Ndp+Binding+Site+For+Residue+C+503'>AC3</scene>, <scene name='pdbsite=AC4:Ndp+Binding+Site+For+Residue+D+504'>AC4</scene>, <scene name='pdbsite=AC5:H11+Binding+Site+For+Residue+A+601'>AC5</scene>, <scene name='pdbsite=AC6:H11+Binding+Site+For+Residue+B+602'>AC6</scene>, <scene name='pdbsite=AC7:H11+Binding+Site+For+Residue+D+603'>AC7</scene> and <scene name='pdbsite=AC8:H11+Binding+Site+For+Residue+C+604'>AC8</scene> | ||
| + | |LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=H11:'>H11</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] | ||
| + | |GENE= HSD11B1, HSD11, HSD11L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors''' | ||
| + | |||
==About this Structure== | ==About this Structure== | ||
| - | 3BYZ is a [ | + | 3BYZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYZ OCA]. |
[[Category: 11-beta-hydroxysteroid dehydrogenase]] | [[Category: 11-beta-hydroxysteroid dehydrogenase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 29: | Line 38: | ||
[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:01:51 2008'' |
Revision as of 17:01, 20 March 2008
| |||||||
| , resolution 2.69Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , and | ||||||
| Ligands: | and | ||||||
| Gene: | HSD11B1, HSD11, HSD11L (Homo sapiens) | ||||||
| Activity: | 11-beta-hydroxysteroid dehydrogenase, with EC number 1.1.1.146 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors
About this Structure
3BYZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Page seeded by OCA on Thu Mar 20 19:01:51 2008
Categories: 11-beta-hydroxysteroid dehydrogenase | Homo sapiens | Single protein | Jordan, S R. | Li, V. | Zhang, J. | H11 | NDP | 3-layer (aba) sandwich | Alpha beta | Endoplasmic reticulum | Glycoprotein | Lipid metabolism | Membrane | Microsome | Nad(p)-binding rossmann-like domain. amino thiazole inhibitor | Nadp | Oxidoreductase | Polymorphism | Rossmann fold | Signal-anchor | Steroid metabolism | Transmembrane
