4zkf

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'''Unreleased structure'''
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==Crystal structure of human phosphodiesterase==
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<StructureSection load='4zkf' size='340' side='right' caption='[[4zkf]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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The entry 4zkf is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>
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Authors: Kim, S.Y., Kohno, T., Mori, T., Kitano, K., Hakoshima, T.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [http://www.ebi.ac.uk/pdbsum/4zkf PDBsum]</span></td></tr>
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Description: Crystal structure of human phosphodiesterase
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Kohno, T]]
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[[http://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Hakoshima, T]]
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[[Category: Kim, S Y]]
[[Category: Kitano, K]]
[[Category: Kitano, K]]
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[[Category: Kim, S.Y]]
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[[Category: Kohno, T]]
[[Category: Mori, T]]
[[Category: Mori, T]]
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[[Category: Hakoshima, T]]
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[[Category: Diesterase]]
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[[Category: Hydrolase]]

Revision as of 15:32, 17 June 2015

Crystal structure of human phosphodiesterase

4zkf, resolution 1.82Å

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