Urokinase
From Proteopedia
(Difference between revisions)
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**[[1ejn]] - hUK (mutant) + urea derivative inhibitor<br /> | **[[1ejn]] - hUK (mutant) + urea derivative inhibitor<br /> | ||
**[[2vin]], [[2vio]], [[2vip]], [[2viq]], [[2viv]], [[2viw]] - hUK (mutant) + mexiletine derivative<br /> | **[[2vin]], [[2vio]], [[2vip]], [[2viq]], [[2viv]], [[2viw]] - hUK (mutant) + mexiletine derivative<br /> | ||
| - | **[[3qn7]], [[4jk5]], [[4jk6]] - hUK (mutant) + peptide inhibitor<br /> | + | **[[3qn7]], [[4jk5]], [[4jk6]], [[4x1n]], [[4x1q]], [[4x1r]] - hUK (mutant) + peptide inhibitor<br /> |
| - | **[[4mnw]], [[4mnx]], [[4mny]] - hUK (mutant) + bicyclic peptide <br /> | + | **[[4mnw]], [[4mnx]], [[4mny]], [[4os1]], [[4os2]], [[4os4]], [[4os5]], [[4os6]], [[4os7]] - hUK (mutant) + bicyclic peptide <br /> |
**[[2vnt]], [[2r2w]] - hUK + guanidine derivative<br /> | **[[2vnt]], [[2r2w]] - hUK + guanidine derivative<br /> | ||
**[[1w0z]], [[1w10]], [[1w11]], [[1w12]], [[1w13]], [[1w14]] - hUK + alanineamide derivative<br /> | **[[1w0z]], [[1w10]], [[1w11]], [[1w12]], [[1w13]], [[1w14]] - hUK + alanineamide derivative<br /> | ||
Revision as of 07:09, 25 June 2015
Urokinase (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage into catalytic domain (residues 179-431) and short chain (residues 156-178).
3D Structures of urokinase
Updated on 25-June-2015
