Beta-adrenergic receptor kinase

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> Beta adrenergic receptor kinase (BARK) is an intracellular serine/threonine kinase. B...)
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<StructureSection load='3uzt' size='340' side='right' caption='Human BARK1 complex with RNA (PDB code [[3uzt]])' scene=''>
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Beta adrenergic receptor kinase (BARK) is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adregenic receptor (BAR) when it is occupied by the agonist thus causing its desensitization. BARK belongs to the family of G protein-coupled receptor kinase (GRK).
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
 
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Beta adrenergic receptor kinase (BARK) is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adregenic receptor (BAR) when it is occupied by the agonist thus causing its desensitization.
 
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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== 3D Structures of β adrenergic receptor kinase ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1ym7]] – bBARK1 (mutant) - bovine <BR />
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[[4pnk]], [[3cik]] – hBARK1 + guanine-nucleotide binding protein G b,g subunits – human <BR />
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[[4mk0]], [[3v5w]] – hBARK1 + guanine-nucleotide binding protein G b,g subunits + paroxetine derivative<BR />
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[[3uzs]] – hBARK1 (mutant) + guanine-nucleotide binding protein G b,g subunits + RNA <BR />
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[[3uzt]] – hBARK1 (mutant) + RNA <BR />
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[[3psc]] – hBARK1 (mutant) + guanine-nucleotide binding protein G b,g subunits <BR />
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[[3krw]], [[3krx]] – hBARK1 + guanine-nucleotide binding protein G b,g subunits + inhibitor<BR />
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[[3pvu]], [[3pvw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G b,g subunits + inhibitor <BR />
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[[2bcj]] – bBARK1 (mutant) + guanine-nucleotide binding protein G a,b,g subunits <BR />
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[[1omw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G b,g subunits <BR />
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</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Revision as of 10:26, 25 June 2015

Human BARK1 complex with RNA (PDB code 3uzt)

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References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Cristina Murga, Joel L. Sussman

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