Beta-adrenergic receptor kinase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3uzt' size='340' side='right' caption='Human BARK1 complex with RNA (PDB code [[3uzt]])' scene=''> | + | <StructureSection load='3uzt' size='340' side='right' caption='Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code [[3uzt]])' scene=''> |
Beta adrenergic receptor kinase (BARK) is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adregenic receptor (BAR) when it is occupied by the agonist thus causing its desensitization. BARK belongs to the family of G protein-coupled receptor kinase (GRK). | Beta adrenergic receptor kinase (BARK) is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adregenic receptor (BAR) when it is occupied by the agonist thus causing its desensitization. BARK belongs to the family of G protein-coupled receptor kinase (GRK). | ||
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[[1ym7]] – bBARK1 (mutant) - bovine <BR /> | [[1ym7]] – bBARK1 (mutant) - bovine <BR /> | ||
| - | [[4pnk]], [[3cik]] – hBARK1 + guanine-nucleotide binding protein G | + | [[4pnk]], [[3cik]] – hBARK1 + guanine-nucleotide binding protein G β,γ subunits – human <BR /> |
| - | [[4mk0]], [[3v5w]] – hBARK1 + guanine-nucleotide binding protein G | + | [[4mk0]], [[3v5w]] – hBARK1 + guanine-nucleotide binding protein G β,γ subunits + paroxetine derivative<BR /> |
| - | [[3uzs]] – hBARK1 (mutant) + guanine-nucleotide binding protein G | + | [[3uzs]] – hBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits + RNA <BR /> |
[[3uzt]] – hBARK1 (mutant) + RNA <BR /> | [[3uzt]] – hBARK1 (mutant) + RNA <BR /> | ||
| - | [[3psc]] – hBARK1 (mutant) + guanine-nucleotide binding protein G | + | [[3psc]] – hBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits <BR /> |
| - | [[3krw]], [[3krx]] – hBARK1 + guanine-nucleotide binding protein G | + | [[3krw]], [[3krx]] – hBARK1 + guanine-nucleotide binding protein G β,γ subunits + inhibitor<BR /> |
| - | [[3pvu]], [[3pvw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G | + | [[3pvu]], [[3pvw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits + inhibitor <BR /> |
| - | [[2bcj]] – bBARK1 (mutant) + guanine-nucleotide binding protein G | + | [[2bcj]] – bBARK1 (mutant) + guanine-nucleotide binding protein G α,β,γ subunits <BR /> |
| - | [[1omw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G | + | [[1omw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits <BR /> |
Revision as of 10:32, 25 June 2015
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References
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Cristina Murga, Joel L. Sussman
