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3hla
From Proteopedia
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| - | [[Image:3hla.jpg|left|200px]] | + | [[Image:3hla.jpg|left|200px]] |
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| - | '''SPECIFICITY POCKETS FOR THE SIDE CHAINS OF PEPTIDE ANTIGENS IN HLA-AW68''' | + | {{Structure |
| + | |PDB= 3hla |SIZE=350|CAPTION= <scene name='initialview01'>3hla</scene>, resolution 2.6Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''SPECIFICITY POCKETS FOR THE SIDE CHAINS OF PEPTIDE ANTIGENS IN HLA-AW68''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 3HLA is a [ | + | 3HLA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLA OCA]. |
==Reference== | ==Reference== | ||
| - | Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution., Saper MA, Bjorkman PJ, Wiley DC, J Mol Biol. 1991 May 20;219(2):277-319. PMID:[http:// | + | Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution., Saper MA, Bjorkman PJ, Wiley DC, J Mol Biol. 1991 May 20;219(2):277-319. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2038058 2038058] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: histocompatibility antigen]] | [[Category: histocompatibility antigen]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:05:16 2008'' |
Revision as of 17:05, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
SPECIFICITY POCKETS FOR THE SIDE CHAINS OF PEPTIDE ANTIGENS IN HLA-AW68
Contents |
Overview
The three-dimensional structure of the human histocompatibility antigen HLA-A2 was determined at 3.5 A resolution by a combination of isomorphous replacement and iterative real-space averaging of two crystal forms. The monoclinic crystal form has now been refined by least-squares methods to an R-factor of 0.169 for data from 6 to 2.6 A resolution. A superposition of the structurally similar domains found in the heterodimer, alpha 1 onto alpha 2 and alpha 3 onto beta 2m, as well as the latter pair onto the ancestrally related immunoglobulin constant domain, reveals that differences are mainly in the turn regions. Structural features of the alpha 1 and alpha 2 domains, such as conserved salt-bridges that contribute to stability, specific loops that form contacts with other domains, and the antigen-binding groove formed from two adjacent helical regions on top of an eight-stranded beta-sheet, are analyzed. The interfaces between the domains, especially those between beta 2m and the HLA heavy chain presumably involved in beta 2m exchange and heterodimer assembly, are described in detail. A detailed examination of the binding groove confirms that the solvent-accessible amino acid side-chains that are most polymorphic in mouse and human alleles fill up the central and widest portion of the binding groove, while conserved side-chains are clustered at the narrower ends of the groove. Six pockets or sub-sites in the antigen-binding groove, of diverse shape and composition, appear suited for binding side-chains from antigenic peptides. Three pockets contain predominantly non-polar atoms; but others, especially those at the extreme ends of the groove, have clusters of polar atoms in close proximity to the "extra" electron density in the binding site. A possible role for beta 2m in stabilizing permissible peptide complexes during folding and assembly is presented.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
3HLA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution., Saper MA, Bjorkman PJ, Wiley DC, J Mol Biol. 1991 May 20;219(2):277-319. PMID:2038058
Page seeded by OCA on Thu Mar 20 19:05:16 2008
