Tissue factor pathway inhibitor
From Proteopedia
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<StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domai II (grey and green) complex with trypsin (pink and yellow) and Ca+2 ion (PDB code [[1tfx]]) comp' scene=''> | <StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domai II (grey and green) complex with trypsin (pink and yellow) and Ca+2 ion (PDB code [[1tfx]]) comp' scene=''> | ||
| - | '''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel | + | '''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel β sheet followed by an α helix. Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa. |
== Function == | == Function == | ||
Revision as of 06:40, 16 July 2015
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3D Structures of tissue factor pathway inhibitor
Updated on 16-July-2015
1adz – hTFPI-1 kunitz domain II (mutant) – human - NMR
1irh – hTFPI-1 kunitz domain III - NMR
1tfx – hTFPI-1 kunitz domain II + trypsin
1zr0 – hTFPI-2 kunitz domain I + trypsin
4dtg – hTFPI-1 kunitz domain II + antibody
4bqd – hTFPI-1 kunitz domain I + peptide
