4zto
From Proteopedia
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| - | ''' | + | ==Fab/epitope complex structure of rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region== |
| + | <StructureSection load='4zto' size='340' side='right' caption='[[4zto]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4zto]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTO FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ztp|4ztp]], [[4zyt|4zyt]], [[4zyu|4zyu]], [[4zyv|4zyv]], [[4zyw|4zyw]], [[4zyx|4zyx]], [[4zyy|4zyy]], [[4zyz|4zyz]], [[4zz0|4zz0]], [[4zz2|4zz2]], [[4zz3|4zz3]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zto RCSB], [http://www.ebi.ac.uk/pdbsum/4zto PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The fourth conserved region (C4) in the HIV-1 envelope glycoprotein (Env) gp120 is a structural element that is important for its function, as it binds to both the receptor CD4 and the co-receptor CCR5/CXCR4. It has long been known that this region is highly immunogenic and that it harbors B-cell as well as T-cell epitopes. It is the target of a number of antibodies in animal studies, which are called CD4-blockers. However, the mechanism by which the virus shields itself from such antibody responses is not known. Here, we determined the crystal structure of R53 in complex with its epitope peptide using a novel anti-C4 rabbit monoclonal antibody R53. Our data show that although the epitope of R53 covers a highly conserved sequence (433)AMYAPPI(439), it is not available in the gp120 trimer and in the CD4-bound conformation. Our results suggest a masking mechanism to explain how HIV-1 protects this critical region from the human immune system. | ||
| - | + | Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding.,Pan R, Chen Y, Vaine M, Hu G, Wang S, Lu S, Kong XP Emerg Microbes Infect. 2015 Jul;4(7):e44. doi: 10.1038/emi.2015.44. Epub 2015 Jul, 15. PMID:26251831<ref>PMID:26251831</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kong, X P]] | ||
[[Category: Pan, R]] | [[Category: Pan, R]] | ||
| - | [[Category: | + | [[Category: C4]] |
| + | [[Category: Cd4]] | ||
| + | [[Category: Env]] | ||
| + | [[Category: Hiv-1]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Monoclonal antibody]] | ||
Revision as of 12:11, 20 August 2015
Fab/epitope complex structure of rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region
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Categories: Kong, X P | Pan, R | C4 | Cd4 | Env | Hiv-1 | Immune system | Monoclonal antibody
