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4wci

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'''Unreleased structure'''
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==Crystal structure of the 1st SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 378-393) from human RIN3==
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<StructureSection load='4wci' size='340' side='right' caption='[[4wci]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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The entry 4wci is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4wci]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WCI FirstGlance]. <br>
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Authors: Rouka, E., Simister, P.C., Janning, M., Kirsch, K.H., Krojer, T., Knapp, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Feller, S.M., Structural Genomics Consortium (SGC)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u23|3u23]]</td></tr>
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Description: Crystal structure of the 1st SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 378-393) from human RIN3
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wci RCSB], [http://www.ebi.ac.uk/pdbsum/4wci PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Feller, S.M]]
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== Disease ==
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[[Category: Kirsch, K.H]]
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[[http://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN]] Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3) [MIM:[http://omim.org/entry/607832 607832]]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:12764198</ref>
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[[Category: Knapp, S]]
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== Function ==
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[[http://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN]] Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.<ref>PMID:15800069</ref> [[http://www.uniprot.org/uniprot/RIN3_HUMAN RIN3_HUMAN]] Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.<ref>PMID:12972505</ref> <ref>PMID:21586568</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M]]
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[[Category: Feller, S M]]
[[Category: Janning, M]]
[[Category: Janning, M]]
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[[Category: Simister, P.C]]
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[[Category: Kirsch, K H]]
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[[Category: Rouka, E]]
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[[Category: Knapp, S]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
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[[Category: Bountra, C]]
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[[Category: Rouka, E]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Structural genomic]]
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[[Category: Von Delft, F]]
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[[Category: Simister, P C]]
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[[Category: Edwards, A.M]]
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[[Category: Endocytosis adaptor protein protein-peptide binary complex kidney]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]

Revision as of 12:24, 20 August 2015

Crystal structure of the 1st SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 378-393) from human RIN3

4wci, resolution 1.65Å

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