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1f15

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Revision as of 10:50, 10 September 2015

CUCUMBER MOSAIC VIRUS (STRAIN FNY)

Structural highlights

1f15 is a 3 chain structure with sequence from Cmv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[CAPSD_CMVFN] Capsid protein. Probably binds RNA and plays a role in packaging (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The structure of cucumber mosaic virus (CMV; strain Fny) has been determined to a 3.2-A resolution using X-ray crystallography. Despite the fact that CMV has only 19% capsid protein sequence identity (34% similarity) to cowpea chlorotic mottle virus (CCMV), the core structures of these two members of the Bromoviridae family are highly homologous. As suggested by a previous low-resolution structural study, the 305-A diameter (maximum) of CMV is approximately 12 A larger than that of CCMV. In CCMV, the structures of the A, B, and C subunits are nearly identical except in their N termini. In contrast, the structures of two loops in subunit A of CMV differ from those in B and C. These loops are 6 and 7 residues longer than the analogous regions in CCMV. Unlike that of CCMV, the capsid of CMV does not undergo swelling at pH 7.0 and is stable at pH 9.0. This may be partly due to the fact that the N termini of the B and C subunits form a unique bundle of six amphipathic helices oriented down into the virion core at the threefold axes. In addition, while CCMV has a cluster of aspartic acid residues at the quasi-threefold axis that are proposed to bind metal in a pH-dependent manner, this cluster is replaced by complementing acids and bases in CMV. Finally, this structure clearly demonstrates that the residues important for aphid transmission lie at the outermost portion of the betaH-betaI loop and yields details of the portions of the virus that are hypothesized to mediate binding to aphid mouthparts.

The structure of cucumber mosaic virus and comparison to cowpea chlorotic mottle virus.,Smith TJ, Chase E, Schmidt T, Perry KL J Virol. 2000 Aug;74(16):7578-86. PMID:10906212^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Smith TJ, Chase E, Schmidt T, Perry KL. The structure of cucumber mosaic virus and comparison to cowpea chlorotic mottle virus. J Virol. 2000 Aug;74(16):7578-86. PMID:10906212

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f15"

@@ Line 2: / Line 2: @@
 <StructureSection load='1f15' size='340' side='right' caption='[[1f15]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1f15]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F15 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F15 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1f15]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cmv Cmv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F15 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F15 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f15 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f15 RCSB], [http://www.ebi.ac.uk/pdbsum/1f15 PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f15 OCA], [http://pdbe.org/1f15 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f15 RCSB], [http://www.ebi.ac.uk/pdbsum/1f15 PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/COAT_CMVFN COAT_CMVFN]] Capsid protein. Probably binds RNA and plays a role in packaging (By similarity).
+[[http://www.uniprot.org/uniprot/CAPSD_CMVFN CAPSD_CMVFN]] Capsid protein. Probably binds RNA and plays a role in packaging (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 25: / Line 25: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1f15" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 32: / Line 33: @@
 __TOC__
 </StructureSection>
-[[Category: Viruses]]
+[[Category: Cmv]]
 [[Category: Chase, E]]
 [[Category: Perry, K]]

1f15

From Proteopedia

Revision as of 10:50, 10 September 2015

CUCUMBER MOSAIC VIRUS (STRAIN FNY)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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