2ezp
From Proteopedia
(Difference between revisions)
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<StructureSection load='2ezp' size='340' side='right' caption='[[2ezp]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | <StructureSection load='2ezp' size='340' side='right' caption='[[2ezp]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ezp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ezp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Civ Civ]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EZP FirstGlance]. <br> |
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ezo|2ezo]], [[2ezq|2ezq]], [[2ezr|2ezr]], [[2ezs|2ezs]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ezo|2ezo]], [[2ezq|2ezq]], [[2ezr|2ezr]], [[2ezs|2ezs]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ezp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ezp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ezp RCSB], [http://www.ebi.ac.uk/pdbsum/2ezp PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ezp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ezp OCA], [http://pdbe.org/2ezp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ezp RCSB], [http://www.ebi.ac.uk/pdbsum/2ezp PDBsum]</span></td></tr> |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/Q88028_SIVCZ Q88028_SIVCZ]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2ezp" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Civ]] |
[[Category: Caffrey, M]] | [[Category: Caffrey, M]] | ||
[[Category: Clore, G M]] | [[Category: Clore, G M]] | ||
Revision as of 12:24, 10 September 2015
SOLUTION NMR STRUCTURE OF ECTODOMAIN OF SIV GP41, MODELS 1-10 OF AN ENSEMBLE OF 40 SIMULATED ANNEALING STRUCTURES
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