1o7z

From Proteopedia

(Difference between revisions)

Revision as of 13:51, 10 September 2015

CRYSTAL STRUCTURE OF IP-10 T-FORM

Structural highlights

1o7z is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1lv9, 1o7y, 1o80
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[CXL10_HUMAN] Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

We have determined the structure of wild-type IP-10 from three crystal forms. The crystals provide eight separate models of the IP-10 chain, all differing substantially from a monomeric IP-10 variant examined previously by NMR spectroscopy. In each crystal form, IP-10 chains form conventional beta sheet dimers, which, in turn, form a distinct tetrameric assembly. The M form tetramer is reminiscent of platelet factor 4, whereas the T and H forms feature a novel twelve-stranded beta sheet. Analytical ultracentrifugation indicates that, in free solution, IP-10 exists in a monomer-dimer equilibrium with a dissociation constant of 9 microM. We propose that the tetrameric structures may represent species promoted by the binding of glycosaminoglycans. The binding sites for several IP-10-neutralizing mAbs have also been mapped.

Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.,Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR Structure. 2003 May;11(5):521-32. PMID:12737818^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR. Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 2003 May;11(5):521-32. PMID:12737818

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o7z"

@@ Line 4: / Line 4: @@
 <table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lv9|1lv9]], [[1o7y|1o7y]], [[1o80|1o80]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [http://www.ebi.ac.uk/pdbsum/1o7z PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [http://pdbe.org/1o7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [http://www.ebi.ac.uk/pdbsum/1o7z PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 26: / Line 26: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1o7z" style="background-color:#fffaf0;"></div>
 ==See Also==

1o7z

From Proteopedia

Revision as of 13:51, 10 September 2015

CRYSTAL STRUCTURE OF IP-10 T-FORM

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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