This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2m5e
From Proteopedia
(Difference between revisions)
| Line 5: | Line 5: | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kxw|2kxw]], [[1exr|1exr]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kxw|2kxw]], [[1exr|1exr]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m5e RCSB], [http://www.ebi.ac.uk/pdbsum/2m5e PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5e OCA], [http://pdbe.org/2m5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m5e RCSB], [http://www.ebi.ac.uk/pdbsum/2m5e PDBsum]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/CALM_PARTE CALM_PARTE]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. [[http://www.uniprot.org/uniprot/SCN2A_RAT SCN2A_RAT]] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | [[http://www.uniprot.org/uniprot/CALM_PARTE CALM_PARTE]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. [[http://www.uniprot.org/uniprot/SCN2A_RAT SCN2A_RAT]] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Calmodulin|Calmodulin]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 20:43, 10 September 2015
Structure of the C-domain of Calcium-saturated Calmodulin bound to the IQ motif of NaV1.2
| |||||||||||
Categories: Feldkamp, M D | Fowler, C A | Shea, M A | Yu, L | Calcium binding protein | Calcium binding protein-metal transport complex | Calcium-binding protein-metal transport complex | Ef-hand | Ion channel gating | Iq motif | Metal binding | Metal transport | Nav1 2 | Neuronal peptide | Sodium channel | Voltage dependent | Voltage gated
