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| - | [[Image:1gw5.gif|left|200px]]<br /> | + | #REDIRECT [[2vgl]] This PDB entry is obsolete and replaced by 2vgl |
| - | <applet load="1gw5" size="450" color="white" frame="true" align="right" spinBox="true"
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| - | caption="1gw5, resolution 2.59Å" />
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| - | '''AP2 CLATHRIN ADAPTOR CORE'''<br />
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| - | ==Overview==
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| - | AP2 is the best-characterized member of the family of heterotetrameric, clathrin adaptor complexes that play pivotal roles in many vesicle, trafficking pathways within the cell. AP2 functions in clathrin-mediated, endocytosis, the process whereby cargo enters the endosomal system from, the plasma membrane. We describe the structure of the 200 kDa AP2 "core", (alpha trunk, beta2 trunk, mu2, and sigma2) complexed with the, polyphosphatidylinositol headgroup mimic inositolhexakisphosphate at 2.6 A, resolution. Two potential polyphosphatidylinositide binding sites are, observed, one on alpha and one on mu2. The binding site for Yxxphi, endocytic motifs is buried, indicating that a conformational change, probably triggered by phosphorylation in the disordered mu2 linker, is, necessary to allow ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12086608 (full description)]]
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| - | ==About this Structure==
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| - | 1GW5 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]], [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] and [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with IHP as [[http://en.wikipedia.org/wiki/ligand ligand]]. The following page contains interesting information on the relation of 1GW5 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Structure known Active Site: IHP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GW5 OCA]].
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| - | ==Reference==
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| - | Molecular architecture and functional model of the endocytic AP2 complex., Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ, Cell. 2002 May 17;109(4):523-35. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12086608 12086608]
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| - | [[Category: Clathrin]]
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Mus musculus]]
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| - | [[Category: Protein complex]]
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| - | [[Category: Rattus norvegicus]]
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| - | [[Category: Collins, B.M.]]
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| - | [[Category: Evans, P.R.]]
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| - | [[Category: Mccoy, A.J.]]
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| - | [[Category: Owen, D.J.]]
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| - | [[Category: IHP]]
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| - | [[Category: adaptor]]
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| - | [[Category: endocytosis]]
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:34:10 2007''
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