1dp2

From Proteopedia

(Difference between revisions)

Revision as of 05:10, 11 September 2015

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RHODANESE AND LIPOATE

Structural highlights

1dp2 is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Related:	2ora, 1orb, 1rhd, 1boi, 1boh, 1rhs
Activity:	Thiosulfate sulfurtransferase, with EC number 2.8.1.1
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[THTR_BOVIN] Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron-sulfur complexes and cyanide detoxification. Binds molecular oxygen and sulfur.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Dihydrolipoate is an acceptor of the rhodanese-bound sulfane sulfur atom, as shown by analysis of the elementary steps of the reaction catalyzed by rhodanese. The crystal structure of sulfur-substituted rhodanese complexed with the non-reactive oxidized form of lipoate has revealed that the compound is bound at the enzyme active site, with the dithiolane ring buried in the interior of the cavity and the carboxylic end pointing towards the solvent. One of the sulfur atoms of the ligand in the unproductive complex is relatively close to the sulfane sulfur bound to Cys-247, the sulfur that is transferred during the catalytic reaction. This mode of binding of lipoate is likely to mimic that of dihydrolipoate. The results presented here support the possible role of dihydrolipoate as sulfur-acceptor substrate of rhodanese in an enzymatic reaction that might serve to provide iron-sulfur proteins with inorganic sulfide.

Specific interaction of lipoate at the active site of rhodanese.,Cianci M, Gliubich F, Zanotti G, Berni R Biochim Biophys Acta. 2000 Aug 31;1481(1):103-8. PMID:11004580^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cianci M, Gliubich F, Zanotti G, Berni R. Specific interaction of lipoate at the active site of rhodanese. Biochim Biophys Acta. 2000 Aug 31;1481(1):103-8. PMID:11004580

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dp2"

@@ Line 7: / Line 7: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ora|2ora]], [[1orb|1orb]], [[1rhd|1rhd]], [[1boi|1boi]], [[1boh|1boh]], [[1rhs|1rhs]]</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiosulfate_sulfurtransferase Thiosulfate sulfurtransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.1 2.8.1.1] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dp2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dp2 RCSB], [http://www.ebi.ac.uk/pdbsum/1dp2 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dp2 OCA], [http://pdbe.org/1dp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dp2 RCSB], [http://www.ebi.ac.uk/pdbsum/1dp2 PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 29: / Line 29: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1dp2" style="background-color:#fffaf0;"></div>
 ==See Also==

1dp2

From Proteopedia

Revision as of 05:10, 11 September 2015

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RHODANESE AND LIPOATE

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox