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1vrd

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[[Image:1vrd.gif|left|200px]]
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==Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution==
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<StructureSection load='1vrd' size='340' side='right' caption='[[1vrd]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1vrd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VRD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VRD FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TM1347 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vrd OCA], [http://pdbe.org/1vrd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vrd RCSB], [http://www.ebi.ac.uk/pdbsum/1vrd PDBsum], [http://www.topsan.org/Proteins/JCSG/1vrd TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/Q9X168_THEMA Q9X168_THEMA]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/1vrd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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{{Structure
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==See Also==
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|PDB= 1vrd |SIZE=350|CAPTION= <scene name='initialview01'>1vrd</scene>, resolution 2.18&Aring;
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*[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]]
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|SITE=
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__TOC__
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|LIGAND=
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</StructureSection>
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|ACTIVITY= [http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205]
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|GENE= TM1347 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 Thermotoga maritima MSB8])
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}}
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'''Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution'''
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==About this Structure==
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1VRD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VRD OCA].
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[[Category: IMP dehydrogenase]]
[[Category: IMP dehydrogenase]]
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[[Category: Single protein]]
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[[Category: Thema]]
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[[Category: Thermotoga maritima msb8]]
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[[Category: Structural genomic]]
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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[[Category: Inosine-5'-monophosphate dehydrogenase]]
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[[Category: inosine-5'-monophosphate dehydrogenase]]
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[[Category: Jcsg]]
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[[Category: jcsg]]
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[[Category: Oxidoreductase]]
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[[Category: joint center for structural genomic]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: protein structure initiative]]
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[[Category: Tm1347]]
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[[Category: psi]]
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[[Category: structural genomic]]
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[[Category: tm1347]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:48:43 2008''
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Current revision

Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution

1vrd, resolution 2.18Å

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