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1rh7
From Proteopedia
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|PDB= 1rh7 |SIZE=350|CAPTION= <scene name='initialview01'>1rh7</scene>, resolution 3.106Å | |PDB= 1rh7 |SIZE=350|CAPTION= <scene name='initialview01'>1rh7</scene>, resolution 3.106Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= RETNLB or FIZZ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= RETNLB or FIZZ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam06954 Resistin]</span> | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rh7 OCA], [http://www.ebi.ac.uk/pdbsum/1rh7 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1rh7 RCSB]</span> | ||
}} | }} | ||
| Line 28: | Line 30: | ||
[[Category: Scherer, P E.]] | [[Category: Scherer, P E.]] | ||
[[Category: Shapiro, L.]] | [[Category: Shapiro, L.]] | ||
| - | [[Category: | + | [[Category: glucose uptake]] |
| - | + | [[Category: hormone]] | |
| - | [[Category: hormone | + | |
[[Category: new york structural genomix research consortium]] | [[Category: new york structural genomix research consortium]] | ||
[[Category: nysgxrc]] | [[Category: nysgxrc]] | ||
[[Category: protein structure initiative]] | [[Category: protein structure initiative]] | ||
[[Category: psi]] | [[Category: psi]] | ||
| + | [[Category: resistin/fizz family]] | ||
[[Category: structural genomic]] | [[Category: structural genomic]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:02:53 2008'' |
Revision as of 04:02, 26 March 2008
| |||||||
| , resolution 3.106Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | RETNLB or FIZZ2 (Mus musculus) | ||||||
| Domains: | Resistin | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Resistin-like beta
Overview
Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head" domain and an amino-terminal alpha-helical "tail" segment. The alpha-helical segments associate to form three-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of tail-to-tail hexamers. Analysis of serum samples shows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and trimers. Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin. This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation.
About this Structure
1RH7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:15155948
Page seeded by OCA on Wed Mar 26 06:02:53 2008
Categories: Mus musculus | Single protein | Burley, S K. | NYSGXRC, New York Structural GenomiX Research Consortium. | Patel, S D. | Rajala, M W. | Scherer, P E. | Shapiro, L. | Glucose uptake | Hormone | New york structural genomix research consortium | Nysgxrc | Protein structure initiative | Psi | Resistin/fizz family | Structural genomic
