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1m6r

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[[Image:1m6r.gif|left|200px]]
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==Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang==
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<StructureSection load='1m6r' size='340' side='right' caption='[[1m6r]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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{{Structure
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== Structural highlights ==
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|PDB= 1m6r |SIZE=350|CAPTION= <scene name='initialview01'>1m6r</scene>, resolution 1.54&Aring;
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<table><tr><td colspan='2'>[[1m6r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M6R FirstGlance]. <br>
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|SITE=
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6r OCA], [http://pdbe.org/1m6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m6r RCSB], [http://www.ebi.ac.uk/pdbsum/1m6r PDBsum]</span></td></tr>
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|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>
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</table>
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|ACTIVITY=
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<div style="background-color:#fffaf0;">
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|GENE=
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== Publication Abstract from PubMed ==
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6r OCA], [http://www.ebi.ac.uk/pdbsum/1m6r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m6r RCSB]</span>
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}}
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'''Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang'''
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==Overview==
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The crystal structure of the heptamer rGd(CGCGCG) has been determined at 1.54 A resolution with R(work) and R(free) of 0.191 and 0.235, respectively. The crystal belongs to space group P2(1)2(1)2(1), with unit-cell parameters a = 17.96, b = 31.47, c = 44.73 A and two independent strands in the asymmetric unit. The chimera forms a Z-DNA hexamer duplex d(CGCGCG)(2), with the 5'-overhang rG invisible in the density. The replacement of rG in the 5' terminus of d(GCGCGCG) changes the reverse Hoogsteen G.G base pairing of the 5'-overhang dG (Pan et al., 1997). However, the replacement does not change the helix from Z-form to A-form or the water-structure motifs in the Z-DNA double-helical structure.
The crystal structure of the heptamer rGd(CGCGCG) has been determined at 1.54 A resolution with R(work) and R(free) of 0.191 and 0.235, respectively. The crystal belongs to space group P2(1)2(1)2(1), with unit-cell parameters a = 17.96, b = 31.47, c = 44.73 A and two independent strands in the asymmetric unit. The chimera forms a Z-DNA hexamer duplex d(CGCGCG)(2), with the 5'-overhang rG invisible in the density. The replacement of rG in the 5' terminus of d(GCGCGCG) changes the reverse Hoogsteen G.G base pairing of the 5'-overhang dG (Pan et al., 1997). However, the replacement does not change the helix from Z-form to A-form or the water-structure motifs in the Z-DNA double-helical structure.
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==About this Structure==
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Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5'-(rG) overhang.,Pan B, Sundaralingam M Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):433-7. Epub 2003, Feb 21. PMID:12595699<ref>PMID:12595699</ref>
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1M6R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6R OCA].
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==Reference==
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Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5'-(rG) overhang., Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):433-7. Epub 2003, Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595699 12595699]
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[[Category: Protein complex]]
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[[Category: Pan, B.]]
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[[Category: Sundaralingam, M.]]
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[[Category: overhang]]
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[[Category: z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:12:07 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1m6r" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Pan, B]]
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[[Category: Sundaralingam, M]]
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[[Category: Dna]]
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[[Category: Overhang]]
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[[Category: Z-dna]]

Current revision

Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang

1m6r, resolution 1.54Å

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