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1im1
From Proteopedia
(Difference between revisions)
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<StructureSection load='1im1' size='340' side='right' caption='[[1im1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='1im1' size='340' side='right' caption='[[1im1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1im1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1im1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conim Conim]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IM1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IM1 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1im1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1im1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1im1 RCSB], [http://www.ebi.ac.uk/pdbsum/1im1 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1im1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1im1 OCA], [http://pdbe.org/1im1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1im1 RCSB], [http://www.ebi.ac.uk/pdbsum/1im1 PDBsum]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1im1" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Conim]] |
[[Category: Luginbuhl, P]] | [[Category: Luginbuhl, P]] | ||
[[Category: Mccabe, R T]] | [[Category: Mccabe, R T]] | ||
Revision as of 23:28, 11 September 2015
NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1, 20 STRUCTURES
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