Ethan Farmer AP-1 Binding Site Sandbox

Activator Protein-1 (AP-1) is a family of transcription factors that are involved in the final step of different signal transduction cascades that end in the binding of these AP-1 transcription factors to specific DNA-binding sites called the AP-1 active sites.2 The family includes leucine zipper proteins Jun (c-Jun (PDB: 1JUN), JunB and JunD) and Fos (c-Fos, FosB, Fra-1 and Fra-2) factors, as well as activation partner proteins and small subfamilies.3 The active sites are promoters on a multitude of genes and the specific DNA sequences are different for the different transcription factors within the family, but are conserved among those specific factors.2 This family of transcription factors are mainly involved in regulation of cell proliferation and death as well as various immune responses.3,4 The AP-1 site has been studied for its ability to contribute to the oncogenetic ability of a cell, but physiological information on the AP-1 binding site is still lacking.1

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Structure of Fos and Jun

DNA Interaction

AP-1 Function

AP-1 Regulation

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