Elizeu/sandbox/citocromo c
From Proteopedia
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==Protein's Impacts/solutions== | ==Protein's Impacts/solutions== | ||
Many cancers are made exceedingly invasive when tumors are subjected to hypoxic stresses triggered by a decrease of oxygen in the tumor’s microenvironment or by aspects involved with inflammation. Hypoxic stress increases tumor growth, metastasis, invasiveness and resistance to treatments. When under hypoxic stress the pH of the tumor’s microenvironment decreases while the pH inside the tumor stays fairly normal and when this differential environment is altered it is fatal to the tumor cells. Carbonic anhydrase IX influences the differential pH and when it is inhibited it decreases tumor growth and enhances the effectiveness of cancer treatments. Saccharin binds to CA IX with nanomolar affinity thus inhibiting CA IX. | Many cancers are made exceedingly invasive when tumors are subjected to hypoxic stresses triggered by a decrease of oxygen in the tumor’s microenvironment or by aspects involved with inflammation. Hypoxic stress increases tumor growth, metastasis, invasiveness and resistance to treatments. When under hypoxic stress the pH of the tumor’s microenvironment decreases while the pH inside the tumor stays fairly normal and when this differential environment is altered it is fatal to the tumor cells. Carbonic anhydrase IX influences the differential pH and when it is inhibited it decreases tumor growth and enhances the effectiveness of cancer treatments. Saccharin binds to CA IX with nanomolar affinity thus inhibiting CA IX. | ||
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==Critical Amino Acids== | ==Critical Amino Acids== | ||
Revision as of 20:36, 8 October 2015
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Contents |
Description of Protein/Function
4RIU is a one chain structure that is 260 amino acids long. It is a transmembrane homodimeric enzyme with an extracellularly positioned catalytic domain. 4RIU's functions include bone resorption, regulation of fluid secretion into anterior chamber of eye and catalyzing the hydration of CO2 to HCO3− and a proton.
Ligands
3QR, Jmol GOL, Jmol ZN
Background Names/Origin of Protein
Protein's Impacts/solutions
Many cancers are made exceedingly invasive when tumors are subjected to hypoxic stresses triggered by a decrease of oxygen in the tumor’s microenvironment or by aspects involved with inflammation. Hypoxic stress increases tumor growth, metastasis, invasiveness and resistance to treatments. When under hypoxic stress the pH of the tumor’s microenvironment decreases while the pH inside the tumor stays fairly normal and when this differential environment is altered it is fatal to the tumor cells. Carbonic anhydrase IX influences the differential pH and when it is inhibited it decreases tumor growth and enhances the effectiveness of cancer treatments. Saccharin binds to CA IX with nanomolar affinity thus inhibiting CA IX.
Critical Amino Acids
Leu 198, Leu91, Val, Phe
References
Proteopedia Page Contributors and Editors (what is this?)
Julie Langlois, Atena Farhangian, Rebecca Holstein, Elizabeth A. Dunlap, Katherine Reynolds, Elizeu Santos, Noam Gonen, Anna Lohning, Idan Ben-Nachum, Brian Ochoa, Shai Biran, Gauri Misra, Shira Weingarten-Gabbay, Keni Vidilaseris, Jamie Costa, Abhinav Mittal, Urs Leisinger, Madison Walberry, Edmond R Atalla, Brett M. Thumm, Brooke Fenn, Joel L. Sussman, Mati Cohen, Vesta Nwankwo, Dotan Shaniv, Gulalai Shah
