DNA polymerase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Family A
+
*DNA polymerase I
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**[[2ajq]] – T7Dpo (mutant) + thioredoxin (mutant) + DNA - Enterobacteria phage T7<br />
+
**[[1taq]] – TaDpo I - ''Thermus aquaticus''<br />
-
**[[1t7p]] - T7Dpo (mutant) + thioredoxin + DNA<br />
+
-
**[[1zyq]], [[1x9m]], [[1x9s]], [[1x9w]], [[1tk0]], [[1skr]], [[1sks]], [[1skw]], [[1sl0]], [[1sl1]], [[1sl2]], [[1t7p]] - T7Dpo (mutant) + thioredoxin + DNA + nucleotide<br />
+
-
**[[1t8e]], [[1tk5]], [[1tk8]], [[1tkd]] - T7Dpo + thioredoxin + DNA + nucleotide<br />
+
-
**[[4i9l]] – RB69Dpo (mutant) – Enterobacteria phage RB69<br />
+
-
**[[4i9q]], [[4j2a]], [[4j2b]], [[4j2d]], [[4j2e]], [[4khn]], [[4khq]], [[4khs]], [[4khu]], [[4khw]], [[4khy]], [[4ki4]], [[4ki6]], [[4m3r]], [[4m3t]], [[4m3u]], [[4m3w]], [[4m3x]], [[4m3y]], [[4m3z]], [[4m41]], [[4m42]], [[4m45]] – RB69Dpo (mutant) + DNA<br />
+
-
**[[2gv9]] – Dpo – ''Herpes simplex'' virus<br />
+
-
**[[2kzz]], [[1d8y]], [[2kzm]] – EcDpo I klenow fragment - ''Escherichia coli''<br />
+
-
**[[1qsl]] - EcDpo I klenow fragment + DNA<br />
+
-
**[[1kfs]], [[1krp]], [[1ksp]], [[1kln]] - EcDpo I klenow fragment (mutant) + DNA<br />
+
-
**[[1kfd]], [[1dpi]] - EcDpo I klenow fragment + nucleotide<br />
+
-
**[[1d9d]], [[1d9f]], [[2kfn]] - EcDpo I klenow fragment + DNA + nucleotide<br />
+
-
**[[2kfz]] - EcDpo I klenow fragment (mutant) + DNA + nucleotide<br />
+
-
**[[1taq]] – TaDpo I (mutant) - ''Thermus aquaticus''<br />
+
**[[1jxe]] – TaDpo I Stoffel fragment<br />
**[[1jxe]] – TaDpo I Stoffel fragment<br />
**[[1ktq]] - TaDpo I klenow fragment<br />
**[[1ktq]] - TaDpo I klenow fragment<br />
**[[5ktq]] – TaDpo I + nucleotide<br />
**[[5ktq]] – TaDpo I + nucleotide<br />
**[[3ojs]], [[3oju]], [[1tau]], [[4dle]], [[4dlg]], [[4elt]], [[4elu]], [[4elv]] - TaDpo I + DNA<br />
**[[3ojs]], [[3oju]], [[1tau]], [[4dle]], [[4dlg]], [[4elt]], [[4elu]], [[4elv]] - TaDpo I + DNA<br />
-
**[[3po4]], [[3po5]], [[3rtv]], [[3sv3]], [[3sv4]], [[3syz]], [[3sz2]], [[4c8k]], [[4c8l]], [[4c8m]], [[4c8n]], [[4c8o]], [[4cch]] - TaDpo I klenow fragment + DNA<br />
+
**[[4flt]], [[4flu]], [[4flv]], [[4flw]], [[4flx]], [[4fly]], [[4flz]], [[4fm0]], [[4fm1]], [[4fm2]] – Dpo I + DNA – ''Pyrococcus abyssi''<br />
-
**[[4bwm]], [[4bwj]] - TaDpo I klenow fragment + DNA + RNA<br />
+
**[[1s5j]] – SsDpo I - ''Sulfolobus solfataricus''<br />
-
**[[3py8]] - TaDpo I klenow fragment (mutant) + DNA<br />
+
**[[3eyz]] - GsDpo I (mutant) + DNA - ''Geobacillus stearothermophilus''<br />
-
**[[3m8r]], [[3m8s]], [[3lwl]], [[3lwm]], [[1qss]], [[1qsy]], [[1qtm]], [[2ktq]], [[3ktq]], [[4ktq]], [[3rr7]], [[3rr8]], [[3rrg]], [[3rrh]], [[3t3f]], [[4df4]], [[4df8]], [[4dfj]], [[4dfk]], [[4dfm]], [[4dfp]]- TaDpo I klenow fragment + DNA + nucleotide<br />
+
**[[3ez5]] - GsDpo I (mutant) + DNA + nucleotide <br />
-
**[[4n56]], [[4n5s]], [[4xiu]] - TaDpo I klenow fragment (mutant) + DNA + nucleotide<br />
+
**[[3pv8]], [[3px0]], [[3px4]], [[3px6]], [[4dqi]], [[4dqp]], [[4dqq]], [[4dqr]], [[4dqs]], [[4ds4]], [[4ds5]], [[4dse]], [[4dsf]], [[4e0d]], [[4ez6]], [[4ez9]], [[4f2r]], [[4f2s]], [[4f3o]], [[4f4k]], [[4f8r]] - GkDpo I (mutant) + DNA – ''Geobacillus kaustophilus''<br />
-
**[[1xwl]] - GsDpo I fragment - ''Geobacillus stearothermophilus''<br />
+
-
**[[2xo7]], [[3hp6]], [[3hpo]], [[2hhq]], [[2hhs]], [[2hht]], [[2hhu]], [[2hhv]], [[2hhw]], [[2hhx]], [[2hvh]], [[2hvi]], [[2hw3]], [[1xc9]], [[1ua0]], [[1ua1]], [[1njw]], [[1njx]], [[1njy]], [[1njz]], [[1nk0]], [[1nk4]], [[1nk5]], [[1nk6]], [[1nk7]], [[1nk8]], [[1nk9]], [[1nkb]], [[1nkc]], [[1nke]], [[1l3s]], [[2bdp]], [[4bdp]], [[2xy5]], [[2xy6]], [[2xy7]], [[2y1i]], [[2y1j]], [[3tan]], [[3tap]], [[3taq]], [[3tar]], [[3thv]], [[4b9l]], [[4b9m]], [[4b9n]], [[4b9s]], [[4b9t]], [[4b9u]], [[4b9v]] - GsDpo I fragment + DNA<br />
+
-
**[[4dsi]], [[4dsj]], [[4dsk]], [[4dsl]], [[4dwi]] - GsDpo I fragment (mutant) + DNA<br />
+
-
**[[3ht3]], [[1u45]], [[1u47]], [[1u48]], [[1u49]], [[1u4b]], [[1l3t]], [[1l3u]], [[1l3v]], [[1l5u]], [[1lv5]], [[3bdp]], [[3ti0]], [[4o0i]], [[4uqg]] - GsDpo I fragment + DNA + nucleotide<br />
+
-
**[[3ti0]] - GsDpo I fragment + DNA + nucleotide - ''Bacillus''<br />
+
-
**[[3ikm]] - hDpo γ1+γ2 - human<br />
+
-
**[[3ikl]], [[2g4c]] - hDpo γ2<br />
+
-
**[[4xvi]], [[4xvk]], [[4xvl]], [[4xvm]] – hDpo nu + DNA<br />
+
-
**[[4p4m]], [[4p4o]], [[4p4p]] - Dpo β + DNA + nucleotide – ''Leishmania infantum''<br />
+
-
*Family B
+
*DNA polymerase I klenow fragment
-
**[[1ih7]] – EpDpo - Enterobacteria phage RB69<br />
+
**[[2kzz]], [[1d8y]], [[2kzm]] – EcDpo I - ''Escherichia coli''<br />
-
**[[3cfo]], [[4i9l]] – EpDpo (mutant)<br />
+
**[[1qsl]] - EcDpo I + DNA<br />
-
**[[1waf]], [[1waj]] - EpDpo + nucleotide<br />
+
**[[1kfs]], [[1krp]], [[1ksp]], [[1kln]] - EcDpo I (mutant) + DNA<br />
-
**[[3uiq]], [[4dtj]], [[4dtm]], [[4dtn]], [[4dto]], [[4dtp]], [[4dtr]], [[4dts]], [[4dtu]], [[4dtx]], [[4du1]], [[4du3]], [[4du4]] - EpDpo + DNA<br />
+
**[[1kfd]], [[1dpi]] - EcDpo I + nucleotide<br />
-
**[[3nci]], [[3lds]], [[3l8b]], [[3cq8]],[[3cfp]], [[3cfr]], [[3kd1]], [[3kd5]], [[4e3s]] - EpDpo (mutant) + DNA<br />
+
**[[1d9d]], [[1d9f]], [[2kfn]] - EcDpo I + DNA + nucleotide<br />
-
**[[3ndk]], [[3ne6]], [[3ngi]], [[3nhg]], [[3nae]], [[3lzj]], [[3lzi]], [[2ozs]], [[2p5g]], [[2dy4]], [[1q9x]], [[1q9y]], [[1ig9]], [[3qep]], [[3rma]], [[3rmb]], [[3rmc]], [[3rmd]], [[3rwu]], [[3s9h]], [[3scx]], [[3si6]], [[3sjj]], [[3snn]], [[3spy]], [[3spz]], [[3sq0]], [[3sq1]], [[3sq2]], [[3sq4]], [[3sun]], [[3suo]], [[3sup]], [[3suq]], [[3tab]], [[3tae]], [[3taf]], [[3tag]], [[4i9q]], [[4j2a]], [[4j2b]], [[4j2d]], [[4j2e]], [[4khn]], [[4khq]], [[4khs]], [[4khu]], [[4khw]], [[4khy]], [[4ki4]], [[4ki6]], [[4m3r]], [[4m3t]], [[4m3u]], [[4m3w]], [[4m3x]], [[4m3y]], [[4m3z]], [[4m41]], [[4m42]], [[4m45]] - EpDpo (mutant) + DNA + nucleotide<br />
+
**[[2kfz]] - EcDpo I (mutant) + DNA + nucleotide<br />
-
**[[1clq]], [[3iuq]] - EpDpo + DNA + nucleotide<br />
+
**[[1ktq]] - TaDpo I <br />
-
**[[2oyq]], [[2ozm]], [[2p5o]], [[2dtu]], [[3qei]], [[3qer]], [[3qes]], [[3qet]], [[3qev]], [[3qew]], [[3qex]], [[3qnn]], [[3qno]], [[4fj5]], [[4fj7]], [[4fj8]], [[4fj9]], [[4fjg]], [[4fjh]], [[4fji]], [[4fjj]], [[4fjk]], [[4fjl]], [[4fjm]], [[4fjn]], [[4fjx]], [[4fk0]], [[4fk2]], [[4fk4]] - EpDpo (mutant) + DNA + nucleotide analog<br />
+
**[[3po4]], [[3po5]], [[3rtv]], [[3sv3]], [[3sv4]], [[3syz]], [[3sz2]], [[4c8k]], [[4c8l]], [[4c8m]], [[4c8n]], [[4c8o]], [[4cch]] - TaDpo I + DNA<br />
-
**[[2atq]] – EpDpo + GP32<br />
+
**[[4bwm]], [[4bwj]] - TaDpo I + DNA + RNA<br />
-
**[[1noy]] – T4Dpo + DNA - Enterobacteria phage T4<br />
+
**[[3py8]] - TaDpo I (mutant) + DNA<br />
-
**[[1noz]] – T4Dpo residues 1-388<br />
+
**[[3m8r]], [[3m8s]], [[3lwl]], [[3lwm]], [[1qss]], [[1qsy]], [[1qtm]], [[2ktq]], [[3ktq]], [[4ktq]], [[3rr7]], [[3rr8]], [[3rrg]], [[3rrh]], [[3t3f]], [[4df4]], [[4df8]], [[4dfj]], [[4dfk]], [[4dfm]], [[4dfp]] - TaDpo I + DNA + nucleotide<br />
-
**[[2ex3]] – Dpo (mutant) + DNA terminal protein – Bacillus phage φ29<br />
+
**[[4n56]], [[4n5s]], [[4xiu]] - TaDpo I (mutant) + DNA + nucleotide<br />
-
**[[2py5]], [[2pzs]], [[1xhz]], [[1xi1]] – BpDpo (mutant) + DNA <br />
+
**[[1xwl]] - GsDpo I <br />
-
**[[2pyj]], [[2pyl]] - BpDpo (mutant) + DNA + nucleotide<br />
+
**[[2xo7]], [[3hp6]], [[3hpo]], [[2hhq]], [[2hhs]], [[2hht]], [[2hhu]], [[2hhv]], [[2hhw]], [[2hhx]], [[2hvh]], [[2hvi]], [[2hw3]], [[1xc9]], [[1ua0]], [[1ua1]], [[1njw]], [[1njx]], [[1njy]], [[1njz]], [[1nk0]], [[1nk4]], [[1nk5]], [[1nk6]], [[1nk7]], [[1nk8]], [[1nk9]], [[1nkb]], [[1nkc]], [[1nke]], [[1l3s]], [[2bdp]], [[4bdp]], [[2xy5]], [[2xy6]], [[2xy7]], [[2y1i]], [[2y1j]], [[3tan]], [[3tap]], [[3taq]], [[3tar]], [[3thv]], [[4b9l]], [[4b9m]], [[4b9n]], [[4b9s]], [[4b9t]], [[4b9u]], [[4b9v]] - GsDpo I + DNA<br />
-
**[[1xhx]] - BpDpo (mutant)<br />
+
**[[4dsi]], [[4dsj]], [[4dsk]], [[4dsl]], [[4dwi]] - GsDpo I (mutant) + DNA<br />
-
**[[4e2i]] – hDpo α subunit β + large T antigen<br />
+
**[[3ht3]], [[1u45]], [[1u47]], [[1u48]], [[1u49]], [[1u4b]], [[1l3t]], [[1l3u]], [[1l3v]], [[1l5u]], [[1lv5]], [[3bdp]], [[3ti0]], [[4o0i]], [[4uqg]] - GsDpo I + DNA + nucleotide<br />
-
**[[4bpx]] - hDpo α catalytic subunit + DNA primase small subunit <br />
+
 
-
**[[4q5v]] - hDpo α catalytic subunit + DNA + RNA + aphidicolin <br />
+
*DNA polymerase II
-
**[[4qcl]] - hDpo α catalytic subunit + DNA + RNA + nucleotide <br />
+
 
-
**[[2keb]] - hDpo αB - NMR <br />
+
**[[3maq]], [[3k57]], [[3k58]], [[3k59]], [[3k5l]], [[3k5m]] - EcDpo II (mutant) + DNA + nucleotide <br />
-
**[[1n5g]], [[1k0p]], [[1k18]] - hDpo α zinc finger domain- NMR<br />
+
-
**[[1zqj]], [[4lvs]], [[4m2y]], [[4m47]], [[4nlk]], [[4nln]], [[4nlz]], [[4nm1]], [[4nm2]], [[4tup]], [[4tuq]], [[4tur]], [[4tus]] – hDpo β + DNA<br />
+
-
**[[4m9g]], [[4m9h]], [[4m9j]], [[4m9l]], [[4m9n]], [[4r63]], [[4r64]], [[4r65]], [[4r66]] – hDpo β (mutant) + DNA<br />
+
-
**[[3rje]], [[3rjf]], [[3rjg]], [[3rjh]], [[3rji]], [[3rjj]], [[3rjk]], [[3tfr]], [[3tfs]], [[4mf2]], [[4mf8]], [[4mfa]], [[4mfc]], [[4mff]], [[4nxz]], [[4ny8]], [[4o5c]], [[4o5e]], [[4o5k]], [[4o9m]], [[4p2h]], [[4pgq]], [[4pgx]], [[4pha]], [[4phd]], [[4uaw]], [[4uay]], [[4uaz]], [[4ub1]], [[4ub2]], [[4ub3]], [[4ub4]], [[4ub5]], [[4ubb]], [[4ubc]] - hDpo β + nucleotide + DNA<br />
+
-
**[[4ppx]] - hDpo β + spiroiminohydantoin + DNA<br />
+
-
**[[3e0j]] - hDpo δ2+δ3<br />
+
-
**[[3mr4]], [[3mr2]], [[3mr3]], [[3mr5]], [[3mr6]] - hDpo ε catalytic core + DNA + nucleotide<br />
+
-
**[[3tq1]], [[4j9k]], [[4j9l]], [[4j9m]], [[4j9n]], [[4j9o]], [[4j9p]], [[4j9q]], [[4j9r]], [[4j9s]] - hDpo η catalytic core + DNA<br />
+
-
**[[4dl2]], [[4dl3]], [[4dl4]], [[4dl5]], [[4dl6]], [[4dl7]], [[4eey]] - hDpo η + DNA + nucleotide<br />
+
-
**[[3oiq]] - yDpo α + cell division control protein 13 – yeast<br />
+
-
**[[3flo]], [[3lgb]] - yDpo α subunits A,B<br />
+
-
**[[4b08]], [[4fvm]] - yDpo α subunit A<br />
+
-
**[[4fxd]], [[4fyd]] - yDpo α subunit A + RNA + DNA<br />
+
-
**[[3iay]] - yDpo δ catalytic subunit + DNA<br />
+
-
**[[3oha]], [[3ohb]], [[3mfh]] - yDpo ε (mutant) + DNA<br />
+
-
**[[3mfi]], [[4m8o]] - yDpo ε (mutant) + DNA + nucleotide <br />
+
-
**[[2r8j]], [[2r8k]], [[4ptf]] - yDpo ε catalytic domain + DNA + nucleotide <br />
+
-
**[[2xgp]], [[2xgq]], [[2wtf]] - yDpo ε + DNA<br />
+
-
**[[3maq]], [[3k57]], [[3k58]], [[3k59]], [[3k5l]], [[3k5m]] - EcDpo II (mutant) + DNA + nucleotide<br />
+
**[[3k5n]] - EcDpo II (mutant) + DNA<br />
**[[3k5n]] - EcDpo II (mutant) + DNA<br />
-
**[[3k5o]], [[1q8i]] - EcDpo II (mutant)<br />
+
**[[3k5o]], [[1q8i]] - EcDpo II (mutant) <br />
-
**[[3a2f]] - PfDpo + PCNA - ''Pyrococcus furiosus''<br />
+
**[[3o59]] - PhDpo II large subunit]] - ''Pyrococcus horikoshii''<br />
-
**[[2jgu]], [[4ahc]] - PfDpo<br />
+
**[[2kxe]] - PhDpo II small subunit<br />
-
**[[4ail]] – PfDpo + DNA<br />
+
**[[1qqc]] – DeDpo II – ''Desulfurococcus''<br />
-
**[[1tgo]] - TgDpo – ''Thermococcus gorgonarius''<br />
+
-
**[[2vwj]] – TgDpo (mutant) + DNA <br />
+
-
**[[2vwk]] - TgDpo (mutant)<br />
+
-
**[[2xhb]] - Dpo (mutant) + DNA + ''Thermococcus gorgonarius''<br />
+
-
**[[1wn7]], [[1wns]] – TkDpo B - ''Thermococcus kodakarensis''<br />
+
-
**[[4k8z]] - TkDpo (mutant) + DNA<br />
+
-
**[[1qht]] - ThDpo (mutant) – ''Thermococcus''<br />
+
-
**[[4k8x]] - ThDpo (mutant) + DNA<br />
+
-
**[[1d5a]] – DeDpo – ''Desulfurococcus''<br />
+
-
**[[4flt]], [[4flu]], [[4flv]], [[4flw]], [[4flx]], [[4fly]], [[4flz]], [[4fm0]], [[4fm1]], [[4fm2]] – Dpo + DNA – ''Pyrococcus abyssi''
+
-
*Family C
+
*DNA polymerase III subunit alpha
**[[2hnh]], [[2hqa]] - EcDpo III subunit α catalytic fragment<br />
**[[2hnh]], [[2hqa]] - EcDpo III subunit α catalytic fragment<br />
-
**[[4jom]] - EcDpo III α subunit (mutant)<br />
+
**[[4jom]] - EcDpo III α subunit catalytic fragment (mutant)<br />
**[[2hpi]], [[2hpm]] - TaDpo III α subunit<br />
**[[2hpi]], [[2hpm]] - TaDpo III α subunit<br />
**[[3e0d]] - TaDpo III α subunit + DNA<br />
**[[3e0d]] - TaDpo III α subunit + DNA<br />
**[[3f2b]], [[3f2c]], [[3f2d]], [[4iqj]] – GkDpo III α subunit + DNA + nucleotide <br />
**[[3f2b]], [[3f2c]], [[3f2d]], [[4iqj]] – GkDpo III α subunit + DNA + nucleotide <br />
-
**[[1zd7]], [[1zde]], [[3nzm]] - SyDpo III α subunit – Synechocystis<br />
+
**[[1zd7]], [[1zde]], [[3nzm]] - SyDpo III α subunit – ''Synechocystis''<br />
**[[4gig]] - SyDpo III α subunit (mutant) <br />
**[[4gig]] - SyDpo III α subunit (mutant) <br />
**[[2keq]], [[4kl5]], [[4kl6]] - NpDpo III α subunit – ''Nostoc punctiforme''<br />
**[[2keq]], [[4kl5]], [[4kl6]] - NpDpo III α subunit – ''Nostoc punctiforme''<br />
**[[4lx3]] - NpDpo III α subunit + nucleic acid binding tRNA/helicase<br />
**[[4lx3]] - NpDpo III α subunit + nucleic acid binding tRNA/helicase<br />
-
**[[1ok7]] - EcDpo III + EcDpo IV C-terminal<br />
+
**[[1ok7]] - EcDpo III residues 1-366 + EcDpo IV C-terminal<br />
-
**[[1mmi]], [[2pol]], [[4k3s]], [[4pnv]], [[4pnw]] - EcDpo III subunit β<br />
+
 
-
**[[2xur]], [[3f1v]], [[3pwe]] - EcDpo III subunit β (mutant)<br />
+
*DNA polymerase III subunit beta
 +
 
 +
**[[mmi]], [[2pol]], [[4k3s]], [[4pnv]], [[4pnw]] - EcDpo III subunit β<br />
 +
**[[2xur]], [[3f1v]], [[3pwe]] - EcDpo III subunit β (mutant) <br />
**[[3d1e]] - EcDpo III subunit β + EcDpo II C-terminal<br />
**[[3d1e]] - EcDpo III subunit β + EcDpo II C-terminal<br />
**[[1unn]] - EcDpo III subunit β + EcDpo IV little finger<br />
**[[1unn]] - EcDpo III subunit β + EcDpo IV little finger<br />
-
**[[3d1g]], [[3qsb]], [[4k3k]], [[4k3l]], [[4mjp]], [[4mjq]], [[4mjr]], [[4n94]], [[4n95]], [[4n96]], [[4n97]], [[4n98]], [[4n99]], [[4n9a]], [[4ovf]], [[4ovg]], [[4ovh]], [[4pnu]] - EcDpo III subunit β + inhibitor<br />
+
**[[3d1g]], [[3qsb]], [[4k3k]], [[4k3l]], [[4mjp]], [[4mjq]], [[4mjr]], [[4n94]], [[4n95]], [[4n96]], [[4n97]], [[4n98]], [[4n99]], [[4n9a]], [[4ovf]], [[4ovg]], [[4ovh]], [[4pnu ]] - EcDpo III subunit β + inhibitor<br />
**[[3bep]] - EcDpo III subunit β + DNA<br />
**[[3bep]] - EcDpo III subunit β + DNA<br />
-
**[[3d1f]], [[4k3m]], [[4k3o]], [[4k3p]], [[4k3q]], [[4k3r]], [[4k74]] - EcDpo III β subunit + polypeptide<br />
+
**[[3d1f]], [[3q4j]], [[3q4k]], [[3q4l]], [[4k3l]], [[4k3m]], [[4k3o]], [[4k3p]], [[4k3q]], [[4k3r]], [[4k74]] - EcDpo III β subunit + polypeptide<br />
**[[2avt]] - Dpo III β subunit – ''Streptococcus pyogenes''<br />
**[[2avt]] - Dpo III β subunit – ''Streptococcus pyogenes''<br />
**[[2awa]] - Dpo III β subunit – ''Streptococcus pneumoniae''<br />
**[[2awa]] - Dpo III β subunit – ''Streptococcus pneumoniae''<br />
**[[2p1j]] – TmDpo III exonuclease domain – ''Thermotoga maritima''<br />
**[[2p1j]] – TmDpo III exonuclease domain – ''Thermotoga maritima''<br />
**[[1vpk]] - TmDpo III β subunit<br />
**[[1vpk]] - TmDpo III β subunit<br />
-
**[[3q4j]], [[3q4k]], [[3q4l]], [[3d1f]] - EcDpo III β subunit + peptide<br />
+
**[[4k3s]] - EcDpo III β subunit<br />
-
**[[1njf]], [[1njg]] - EcDpo III subunit γ N-terminal domains 1-2<br />
+
**[[3t0p]] - Dpo III β subunit – ''Eubacterium rectale''<br />
 +
**[[1jqj]], [[1jql]] - EcDpo III subunit β,δ (mutant) <br />
 +
**[[4tr6]] - Pol III β subunit – ''Bacillus subtilis''<br />
 +
**[[3p16]], [[3rb9]], [[4tr7]] - Pol III β subunit – ''Mycobacterrium tuberculosis''<br />
 +
**[[4tr8]] - PaPol III β subunit – ''Pseudomonas aeruginosa''<br />
 +
**[[4tsz]] - PaPol III β subunit + peptide<br />
 +
 
 +
*DNA polymerase III subunit gamma
 +
 
 +
**[[1njf]], [[1njg]] - EcDpo III subunit γ N-terminal domains 1-2<br />
**[[2gno]] - TmDpo III γ subunit<br />
**[[2gno]] - TmDpo III γ subunit<br />
-
**[[1jqj]], [[1jql]] - EcDpo III subunit β, δ(mutant)<br />
+
**[[1xxh]], [[1jr3]] - EcDpo III subunit γ,δ,δ’ <br />
-
**[[1a5t]] - EcDpo III subunit δ’<br />
+
**[[1xxi]] - EcDpo III subunit γ,δ,δ’ + nucleotide<br />
-
**[[1xxh]], [[1jr3]] - EcDpo III subunit γ, δ, δ' <br />
+
 
-
**[[1xxi]] - EcDpo III subunit γ, δ, δ' + nucleotide<br />
+
*DNA polymerase III subunit delta
 +
 
 +
**[[1jqj]], [[1jql]] - EcDpo III subunit β,δ (mutant) <br />
 +
**[[1a5t]] - EcDpo III subunit δ’ <br />
 +
**[[1xxh]], [[1jr3]] - EcDpo III subunit γ,δ,δ’ <br />
 +
**[[1xxi]] - EcDpo III subunit γ,δ,δ’ + nucleotide<br />
 +
**[[3glh]] - EcDpo III subunit δ,δ’,τ <br />
 +
**[[3glf]] - EcDpo III subunit δ,δ’,τ + DNA<br />
 +
**[[3gli]] - EcDpo III subunit δ,δ’,τ,ξ + DNA<br />
 +
**[[3glg]] - EcDpo III subunit δ,δ’,τ (mutant) + DNA<br />
 +
 
 +
*DNA polymerase III subunit epsilon
 +
 
**[[2gui]] – EcDpo III subunit ε N-terminal<br />
**[[2gui]] – EcDpo III subunit ε N-terminal<br />
-
**[[4gx8]], [[4gx9]] - EcDpo III subunit α/ε<βρ />
+
**[[1j53]], [[1j54]] - EcDpo III subunit ε N-terminal exonuclease domain<br />
-
**[[1j53]], [[1j54]], [[2gui]] - EcDpo III subunit ε N-terminal exonuclease domain<br />
+
**[[2ido]] - EcDpo III subunit ε + HOT protein<br />
**[[2ido]] - EcDpo III subunit ε + HOT protein<br />
-
**[[3glh]] - EcDpo III subunit δ, δ', τ <br />
+
**[[4gx8]] - EcDpo III ε subunit/ EcDpo III α subunit<br />
-
**[[3glf]] - EcDpo III subunit δ, δ', τ + DNA<br />
+
**[[4gx9]] - EcDpo III ε subunit/ EcDpo III α subunit (mutant)<br />
-
**[[3gli]] - EcDpo III subunit δ, δ', τ, ξ + DNA<br />
+
**[[2xy8]] - EcDpo III subunit ε,θ<br />
-
**[[3glg]] - EcDpo III subunit δ, δ', τ mutant DNA<br />
+
 
 +
*DNA polymerase III subunit tau
 +
 
 +
**[[2aya]] - EcDpo III subunit τ <br />
 +
**[[3glh]] - EcDpo III subunit δ,δ’,τ <br />
 +
**[[3glf]] - EcDpo III subunit δ,δ’,τ + DNA<br />
 +
**[[3gli]] - EcDpo III subunit δ,δ’,τ,ξ + DNA<br />
 +
**[[3glg]] - EcDpo III subunit δ,δ’,τ (mutant) + DNA<br />
 +
 
 +
*DNA polymerase III subunit xi
 +
 
 +
**[[3gli]] - EcDpo III subunit δ,δ’,τ,ξ + DNA<br />
 +
 
 +
*DNA polymerase III subunit theta
 +
 
**[[2xy8]] - EcDpo III subunit ε,θ<br />
**[[2xy8]] - EcDpo III subunit ε,θ<br />
**[[2axd]], [[2ae9]], [[1du2]] - EcDpo III subunit θ - NMR<br />
**[[2axd]], [[2ae9]], [[1du2]] - EcDpo III subunit θ - NMR<br />
-
**[[2aya]] - EcDpo III subunit τ<br />
+
 
-
**[[1em8]] - EcDpo III subunit φ, χ<br />
+
*DNA polymerase III subunit chi
 +
 
 +
**[[1em8]] - EcDpo III subunit ϕ,χ<br />
**[[3sxu]] - EcDpo III subunit ϕ,χ + peptide<br />
**[[3sxu]] - EcDpo III subunit ϕ,χ + peptide<br />
-
**[[1bgx]] – TaDpo + TP7 MAB<br />
 
-
*Family X
+
*DNA polymerase III subunit phi
-
**[[3q8p]], [[3q8q]], [[3lk9]], [[3mby]], [[3isb]], [[3isc]], [[1zjm]], [[1tv9]], [[1tva]], [[1bpx]], [[1bpz]], [[1zqa]], [[1zqb]], [[1zqc]], [[1zqd]], [[1zqf]], [[1zqg]], [[1zqh]], [[1zqi]], [[1zaj]], [[1zqk]], [[1zql]], [[1zqm]], [[1zqn]], [[1zqo]], [[1zqp]], [[1zqq]], [[1zqr]], [[1zqs]], [[1zqt]], [[1zqu]], [[1zqv]], [[1zqw]], [[1zqx]], [[1zqy]], [[1zqz]], [[7ice]], [[7icf]], [[7ici]], [[7icj]], [[7icl]], [[7icm]], [[7icp]], [[7icr]], [[7ict]], [[7icu]], [[7icv]], [[8icb]], [[8icc]], [[9icj]], [[9ick]], [[9icl]], [[9icm]], [[9icp]], [[9icw]], [[9icx]], [[9icy]], [[7icg]], [[7ich]], [[7ick]], [[7icn]], [[7ico]], [[7icq]], [[7ics]], [[1zqe]], [[4gxi]], [[4gxj]], [[4gxk]], [[4kld]], [[4kle]], [[4klf]], [[4klg]], [[4klh]], [[4kli]], [[4klj]], [[4kll]], [[4klm]], [[4klo]], [[4klp]], [[4klq]], [[4kls]], [[4klt]], [[4klu]], [[1zqj]], [[4lvs]], [[4m2y]], [[4m47]], [[4nlk]], [[4nln]], [[4nlz]], [[4nm1]], [[4nm2]], [[3gdx]], [[3rh4]], [[3rh5]], [[3rh6]] - hDpo β + DNA<br />
+
**[[1em8]] - EcDpo III subunit ϕ,χ<br />
-
**[[3jpn]], [[3jpo]], [[3jpp]], [[3jpq]], [[3jpr]], [[3jpt]], [[3jps]], [[3isd]], [[3c2k]], [[3c2l]], [[3c2m]], [[2pxi]], [[2iso]], [[2isp]], [[2i9g]], [[2fmp]], [[2fmq]], [[2fms]], [[1zjn]], [[1mq2]], [[1mq3]], [[1bpy]], [[8ica]], [[8ice]], [[8icf]], [[8icg]], [[8ich]], [[8ici]], [[8icj]], [[8ick]], [[8icl]], [[8icm]], [[8icn]], [[8ico]], [[8icp]], [[8icq]], [[8icr]], [[8ics]], [[8ict]], [[8icu]], [[8icv]], [[8icw]], [[8icx]], [[8icz]], [[9ice]], [[9icg]], [[9ich]], [[9ici]], [[9icq]], [[9ics]], [[9ict]], [[9icu]], [[9icv]], [[9icr]], [[9icn]], [[9ico]], [[8icy]], [[9ica]], [[9icb]], [[9icc]], [[9icf]], [[4do9]], [[4doa]], [[4dob]], [[4doc]], [[3rje]], [[3rjf]], [[3rjg]], [[3rjh]], [[3rji]], [[3rjj]], [[3rjk]], [[3tfr]], [[3tfs]] - hDpo β + DNA + nucleotide<br />
+
**[[3sxu]] - EcDpo III subunit ϕ,χ + peptide<br />
 +
 
 +
*DNA polymerase IV
 +
 
 +
**[[4ir1]], [[4ir9]], [[4irc]], [[4ird]], [[4irk]] - EcPol IV + DNA<br />
 +
**[[4r8u]] - EcPol IV + DNA + nucleotide<br />
 +
**[[2rdi]] - SsPol IV <br />
 +
**[[3pr4]], [[3pr5]], [[2r8g]], [[2r8h]], [[2r8i]], [[2uvr]], [[2uvu]], [[2uvv]], [[2uvw]] - SsPol IV (mutant) + DNA + nucleotide <br />
 +
**[[4juz]], [[4jv0]], [[4jv1]], [[4jv2]], [[4qw8]], [[4qw9]], [[4qwa]], [[4qwb]], [[4qwc]], [[4qwd]], [[4qwe]], [[4tqr]], [[4tqs]] - SsPol IV + DNA + nucleotide<br />
 +
**[[2xc9]], [[3m9m]], [[3m9n]], [[3m9o]], [[2v4q]], [[2v4r]], [[2ago]], [[1ryr]], [[1rys]], [[2w9a]], [[2w9b]], [[2w9c]], [[3gii]], [[3gij]], [[3gik]], [[3gil]], [[3gim]], [[3qz7]], [[3qz8]], [[3pvx]], [[3pw0]], [[3pw2]], [[3pw4]], [[3pw5]], [[3pw7]], [[3raq]], [[3rax]], [[3rb0]], [[3rb3]], [[3rb4]], [[3rb6]], [[3rbd]], [[3rbe]], [[4hyk]], [[4fbt]], [[4fbu]], [[4g3i]] - SsPol IV + DNA<br />
 +
**[[2xca]], [[2xcp]], [[3khg]], [[3khh]], [[3khl]], [[3khr]], [[2w8k]], [[2w8l]], [[2rdj]], [[2v9w]], [[2va2]], [[2va3]], [[2ia6]], [[2ibk]], [[2jef]], [[2jeg]], [[2jei]], [[2jej]], [[2imw]], [[2j6s]], [[2j6t]], [[2j6u]], [[2asd]], [[2asj]], [[2asl]], [[2atl]], [[2au0]], [[2c22]], [[2c28]], [[2c2d]], [[2c2e]], [[2c2r]], [[2agp]], [[2agq]], [[2bqr]], [[2bqu]], [[2br0]], [[2bq3]], [[1s9f]], [[1s97]], [[1s0m]], [[1s0n]], [[1s0o]], [[1s10]], [[1n48]], [[1n56]], [[1jx4]], [[1jxl]], [[3t5h]], [[3t5j]], [[3t5k]], [[3t5l]], [[3v6h]], [[3v6j]], [[3v6k]], [[4gc6]], [[4gc7]] - SsPol IV + DNA + nucleotide<br />
 +
**[[3fds]] – SsPol IV + PCNA B + PCNA C<br />
 +
**[[3bq2]], [[3bq0]] – SaPol IV + DNA – ''Sulfolobus acidocaldarius''<br />
 +
**[[3bq1]], [[4f4w]], [[4f4x]], [[4f4y]], [[4f4z]], [[4f50]] - SaPol IV + DNA + nucleotide<br />
 +
**[[4nlg]] - SaPol IV (mutant) + DNA<br />
 +
**[[4dez]] – Pol IV – ''Mycobacterium smegmatis''<br />
 +
 
 +
*DNA polymerase from enterobacteria phage T7
 +
 
 +
**[[2ajq]] – T7Dpo (mutant) + thioredoxin (mutant) + DNA <br />
 +
**[[1zyq]], [[1x9m]], [[1x9s]], [[1x9w]], [[1tk0]], [[1skr]], [[1sks]], [[1skw]], [[1sl0]], [[1sl1]], [[1sl2]], [[1t7p]] - T7Dpo (mutant) + thioredoxin + DNA + nucleotide<br />
 +
**[[1t8e]], [[1tk5]], [[1tk8]], [[1tkd]] - T7Dpo + thioredoxin + DNA + nucleotide<br />
 +
 
 +
*DNA polymerase
 +
 
 +
**[[2gv9]] – Dpo – Herpes simplex virus<br />
 +
**[[1bgx]] – TaDpo + TP7 antibody<br />
 +
**[[1ih7]] – EpDpo]] - Enterobacteria phage RB69<br />
 +
**[[3cfo]], [[4i9l]] – EpDpo (mutant) <br />
 +
**[[1waf]], [[1waj]] - EpDpo + nucleotide<br />
 +
**[[3uiq]], [[4dtj]], [[4dtm]], [[4dtn]], [[4dto]], [[4dtp]], [[4dtr]], [[4dts]], [[4dtu]], [[4dtx]], [[4du1]], [[4du3]], [[4du4]] - EpDpo + DNA<br />
 +
**[[3nci]], [[3lds]], [[3l8b]], [[3cq8]], [[3cfp]], [[3cfr]], [[3kd1]], [[3kd5]], [[4e3s]] - EpDpo (mutant) + DNA <br />
 +
**[[3ndk]], [[3ne6]], [[3ngi]], [[3nhg]], [[3nae]], [[3lzj]], [[3lzi]], [[2ozs]], [[2p5g]], [[2dy4]], [[1q9x]], [[1q9y]], [[1ig9]], [[3qep]], [[3rma]], [[3rmb]], [[3rmc]], [[3rmd]], [[3rwu]], [[3s9h]], [[3scx]], [[3si6]], [[3sjj]], [[3snn]], [[3spy]], [[3spz]], [[3sq0]], [[3sq1]], [[3sq2]], [[3sq4]], [[3sun]], [[3suo]], [[3sup]], [[3suq]], [[3tab]], [[3tae]], [[3taf]], [[3tag]], [[4i9q]], [[4j2a]], [[4j2b]], [[4j2d]], [[4j2e]], [[4khn]], [[4khq]], [[4khs]], [[4khu]], [[4khw]], [[4khy]], [[4ki4]], [[4ki6]], [[4m3r]], [[4m3t]], [[4m3u]], [[4m3w]], [[4m3x]], [[4m3y]], [[4m3z]], [[4m41]], [[4m42]], [[4m45]] - EpDpo (mutant) + DNA + nucleotide<br />
 +
**[[1clq]], [[3iuq]] - EpDpo + DNA + nucleotide<br />
 +
**[[2oyq]], [[2ozm]], [[2p5o]], [[2dtu]], [[3qei]], [[3qer]], [[3qes]], [[3qet]], [[3qev]], [[3qew]], [[3qex]], [[3qnn]], [[3qno]], [[4fj5]], [[4fj7]], [[4fj8]], [[4fj9]], [[4fjg]], [[4fjh]], [[4fji]], [[4fjj]], [[4fjk]], [[4fjl]], [[4fjm]], [[4fjn]], [[4fjx]], [[4fk0]], [[4fk2]], [[4fk4]] - EpDpo (mutant) + DNA + nucleotide analog<br />
 +
**[[2atq]] – EpDpo + GP32<br />
 +
**[[1noy]] – T4Dpo + DNA - Enterobacteria phage T4<br />
 +
**[[1noz]] – T4Dpo residues 1-388<br />
 +
**[[2ex3]] – BpDpo (mutant) + DNA terminal protein – Bacillus phage φ29<br />
 +
**[[2py5]], [[2pzs]], [[1xhz]], [[1xi1]] – BpDpo (mutant) + DNA <br />
 +
**[[2pyj]], [[2pyl]] - BpDpo (mutant) + DNA + nucleotide<br />
 +
**[[1xhx]] - BpDpo (mutant) <br />
 +
**[[3a2f]] - PfDpo + PCNA - ''Pyrococcus furiosus''<br />
 +
**[[2jgu]], [[4ahc]] – PfDpo<br />
 +
**[[4ail]] – PfDpo + DNA<br />
 +
**[[1tgo]] - TgDpo – ''Thermococcus gorgonarius''<br />
 +
**[[2vwj]], [[2xhb]] – TgDpo (mutant) + DNA <br />
 +
**[[2vwk]] - TgDpo (mutant) <br />
 +
**[[1wn7]], [[1wns]] – TkDpo B - ''Thermococcus kodakarensis''<br />
 +
**[[4k8z]] - TkDpo (mutant) + DNA<br />
 +
**[[1qht]] - ThDpo (mutant) – Thermococcus<br />
 +
**[[4k8x]] - ThDpo (mutant) + DNA<br />
 +
**[[1d5a]] – DeDpo <br />
 +
 
 +
*DNA polymerase alpha
 +
 
 +
**[[4e2i]] – hDpo α subunit β + large T antigen – human<br />
 +
**[[4bpx]] - hDpo α catalytic subunit + DNA primase small subunit <br />
 +
**[[4q5v]] - hDpo α catalytic subunit + DNA + RNA + aphidicolin <br />
 +
**[[4qcl]] - hDpo α catalytic subunit + DNA + RNA + nucleotide <br />
 +
**[[2keb]] - hDpo αB - NMR <br />
 +
**[[1n5g]], [[1k0p]], [[1k18]] - hDpo α zinc finger domain – NMR<br />
 +
 
 +
*DNA polymerase beta
 +
 
 +
**[[4p4m]], [[4p4o]], [[4p4p]] - Dpo β + DNA + nucleotide – ''Leishmania infantum''<br />
 +
**[[4ppx]] - hDpo β + spiroiminohydantoin + DNA<br />
 +
**[[3q8p]], [[3q8q]], [[3lk9]], [[3mby]], [[3isb]], [[3isc]], [[1zjm]], [[1tv9]], [[1tva]], [[1bpx]], [[1bpz]], [[1zqa]], [[1zqb]], [[1zqc]], [[1zqd]], [[1zqf]], [[1zqg]], [[1zqh]], [[1zqi]], [[1zaj]], [[1zqk]], [[1zql]], [[1zqm]], [[1zqn]], [[1zqo]], [[1zqp1zqq]], [[1zqr]], [[1zqs]], [[1zqt]], [[1zqu]], [[1zqv]], [[1zqw]], [[1zqx]], [[1zqy]], [[1zqz]], [[7ice]], [[7icf]], [[7ici]], [[7icj]], [[7icl]], [[7icm]], [[7icp]], [[7icr]], [[7ict]], [[7icu]], [[7icv]], [[8icb]], [[8icc]], [[9icj]], [[9ick]], [[9icl]], [[9icm]], [[9icp]], [[9icw]], [[9icx]], [[9icy]], [[7icg]], [[7ich]], [[7ick]], [[7icn]], [[7ico]], [[7icq]], [[7ics]], [[1zqe]], [[4gxi]], [[4gxj]], [[4gxk]], [[4kld]], [[4kle]], [[4klf]], [[4klg]], [[4klh]], [[4kli]], [[4klj]], [[4kll]], [[4klm]], [[4klo]], [[4klp]], [[4klq]], [[4kls]], [[4klt]], [[4klu]], [[1zqj]], [[4lvs]], [[4m2y]], [[4m47]], [[4nlk]], [[4nln]], [[4nlz]], [[4nm1]], [[4nm2]], [[3gdx]], [[3rh4]], [[3rh5]], [[3rh6]], [[4tup]], [[4tuq]], [[4tur]], [[4tus]] - hDpo β + DNA<br />
 +
**[[3jpn]], [[3jpo]], [[3jpp]], [[3jpq]], [[3jpr]], [[3jpt]], [[3jps]], [[3isd]], [[3c2k]], [[3c2l]], [[3c2m]], [[2pxi]], [[2iso]], [[2isp]], [[2i9g]], [[2fmp]], [[2fmq]], [[2fms]], [[1zjn]], [[1mq2]], [[1mq3]], [[1bpy]], [[8ica]], [[8ice]], [[8icf]], [[8icg]], [[8ich]], [[8ici]], [[8icj]], [[8ick]], [[8icl]], [[8icm]], [[8icn]], [[8ico]], [[8icp]], [[8icq]], [[8icr]], [[8ics]], [[8ict]], [[8icu]], [[8icv]], [[8icw]], [[8icx]], [[8icz]], [[9ice]], [[9icg]], [[9ich]], [[9ici]], [[9icq]], [[9ics]], [[9ict]], [[9icu]], [[9icv]], [[9icr]], [[9icn]], [[9ico]], [[8icy]], [[9ica]], [[9icb]], [[9icc]], [[9icf]], [[4do9]], [[4doa]], [[4dob]], [[4doc]], [[3rje]], [[3rjf]], [[3rjg]], [[3rjh]], [[3rji]], [[3rjj]], [[3rjk]], [[3tfr]], [[3tfs]], [[4mf2]], [[4mf8]], [[4mfa]], [[4mfc]], [[4mff]], [[4nxz]], [[4ny8]], [[4o5c]], [[4o5e]], [[4o5k]], [[4o9m]], [[4p2h]], [[4pgq]], [[4pgx]], [[4pha]], [[4phd]], [[4uaw]], [[4uay]], [[4uaz]], [[4ub1]], [[4ub2]], [[4ub3]], [[4ub4]], [[4ub5]], [[4ubb]], [[4ubc]] - hDpo β + DNA + nucleotide<br />
**[[2p66]], [[4f5n]] - hDpo β + DNA + nucleotide analog<br />
**[[2p66]], [[4f5n]] - hDpo β + DNA + nucleotide analog<br />
**[[4f5o]], [[4f5p]], [[4f5q]], [[4f5r]] - hDpo β (mutant) + DNA + nucleotide analog<br />
**[[4f5o]], [[4f5p]], [[4f5q]], [[4f5r]] - hDpo β (mutant) + DNA + nucleotide analog<br />
-
**[[3ogu]], [[4jwm]], [[4jwn]], [[4m9g]], [[4m9h]], [[4m9j]], [[4m9l]], [[4m9n]] - hDpo β (mutant) + DNA<br />
+
**[[3ogu]], [[4jwm]], [[4jwn]], [[4m9g]], [[4m9h]], [[4m9j]], [[4m9l]], [[4m9n]], [[4r63]], [[4r64]], [[4r65]], [[4r66]] - hDpo β (mutant) + DNA<br />
-
**[[2v6z]] - hDpo β N-terminal (mutant) - NMR<br />
+
**[[2v6z]] - hDpo β N-terminal (mutant)]] - NMR<br />
**[[3k75]], [[3lqc]] - hDpo β + DNA repair protein XRCC1<br />
**[[3k75]], [[3lqc]] - hDpo β + DNA repair protein XRCC1<br />
 +
**[[1rpl]], [[2bpc]], [[1bpe]], [[1bpb]], [[1bpd]], [[3uxn]] - rDpo β – rat<br />
 +
**[[2van]], [[1jn3]], [[3uxo]], [[3v7l]]- rDpo β (mutant) <br />
 +
**[[1dk2]], [[1dk3]], [[1bno]], [[1bnp]] - rDpo β N-terminal – NMR<br />
 +
**[[1nom]] - rDpo β C-terminal<br />
 +
**[[1huo]], [[1huz]], [[3v7j]] - rDpo β + DNA<br />
 +
**[[3uxp]], [[3v72]], [[3v7k]] - rDpo β (mutant) + DNA <br />
 +
**[[1bpe]] - rDpo β + nucleotide<br />
 +
**[[2bpf]], [[2bpg]] - rDpo β + DNA + nucleotide<br />
 +
**[[3au2]] – TtDpo β + GTP – ''Thermus thermophilus''<br />
 +
**[[3b0x]], [[3b0y]] – TtDpo β (mutant) + GTP<br />
 +
**[[3au6]], [[3auo]] – TtDpo β + GTP + DNA<br />
 +
 +
*DNA polymerase gamma
 +
 +
**[[3ikm]] - hDpo γ1+ γ2 <br />
 +
**[[3ikl]], [[2g4c]] - hDpo γ2<br />
**[[2jw5]] - hDpo λ BRCT domain<br />
**[[2jw5]] - hDpo λ BRCT domain<br />
**[[1xsl]] - hDpo λ catalytic domain<br />
**[[1xsl]] - hDpo λ catalytic domain<br />
Line 182: Line 253:
**[[4k4g]], [[4k4h]], [[4k4i]] - hDpo λ + DNA + nucleotide analog<br />
**[[4k4g]], [[4k4h]], [[4k4i]] - hDpo λ + DNA + nucleotide analog<br />
**[[3mgi]], [[3hw8]], [[3hwt]], [[3hx0]], [[2pfo]], [[2pfp]], [[2pfq]] - hDpo λ (mutant) + DNA + nucleotide<br />
**[[3mgi]], [[3hw8]], [[3hwt]], [[3hx0]], [[2pfo]], [[2pfp]], [[2pfq]] - hDpo λ (mutant) + DNA + nucleotide<br />
 +
 +
*DNA polymerase delta
 +
 +
**[[3e0j]] - hDpo δ2+ δ3<br />
**[[3upq]], [[3uq0]], [[3uq2]] - hDpo δ (mutant) + DNA<br />
**[[3upq]], [[3uq0]], [[3uq2]] - hDpo δ (mutant) + DNA<br />
**[[4fo6]] - hDpo δ (mutant) + DNA + nucleotide analog<br />
**[[4fo6]] - hDpo δ (mutant) + DNA + nucleotide analog<br />
 +
 +
*DNA polymerase epsilon
 +
 +
**[[3mr4]], [[3mr2]], [[3mr3]], [[3mr5]], [[3mr6]] - hDpo ε catalytic core + DNA + nucleotide<br />
 +
 +
*DNA polymerase zeta
 +
 +
**[[3abd]], [[3abe]] - hDpo ζ catalytic subunit Rev3 + mitotic spindle assembly checkpoint protein Rev7<br />
 +
**[[3vu7]], [[4gk0]] - hDpo ζ catalytic subunit + DNA repair protein Rev1 + MAD2B<br />
 +
**[[4fjo]], [[4gk5]] - hDpo κ + hDpo ζ catalytic subunit + DNA repair protein Rev1 + MAD2B<br />
 +
 +
*DNA polymerase eta
 +
 +
**[[2i5o]] - hDpo η ubiquitin-binding zinc finger – NMR<br />
 +
**[[3si8]] - hDpo η + DNA<br />
 +
**[[2lsj]], [[2lsi]] - hDpo η + DNA repair protein Rev1<br />
 +
**[[4dl2]], [[4dl3]], [[4dl4]], [[4dl5]], [[4dl6]], [[4dl7]], [[4eey]], [[4ecq]], [[4ecr]], [[4ecs]], [[4ect]], [[4ecu]], [[4ecv]], [[4ecw]], [[4ecx]], [[4ecy]], [[4ecz]], [[4ed0]], [[4ed1]], [[4ed2]], [[4ed3]], [[4ed6]], [[4ed7]], [[4ed8]], [[4o3n]], [[4o3o]], [[4o3p]], [[4o3q]], [[4o3r]], [[4o3s]], [[4q8e]], [[4q8f]], [[4rnm]], [[4rnn]], [[4rno]], [[4x0p]], [[4x0q]] - hDpo η + DNA + nucleotide<br />
 +
**[[5aga]] - hDpo η + nucleotide<br />
 +
 +
*DNA polymerase iota
 +
 +
**[[3q8r]], [[3q8s]], [[3h4b]], [[3h4d]], [[3gv5]], [[3gv7]], [[3gv8]], [[3epg]], [[3epi]], [[2fll]], [[2fln]], [[2flp]], [[2dpi]], [[2dpj]], [[2alz]], [[1zet]], [[1t3n]], [[4ebc]], [[4ebd]], [[4ebe]], [[4fs1]], [[4fs2]], [[4eyh]], [[4eyi]], [[3g6v]], [[3g6x]], [[3g6y]] - hDpo ι + DNA + nucleotide<br />
 +
**[[3ngd]], [[3osn]], [[3h40]] - hDpo ι catalytic fragment + DNA <br />
 +
**[[2ktf]] - hDpo ι + ubiquitin<br />
 +
**[[2l0f]], [[2l0g]] - hDpo ι + ubiquitin – NMR<br />
 +
**[[2khu]] - hDpo ι ubiquitin binding motif – NMR<br />
 +
**[[2khw]] - hDpo ι ubiquitin binding motif + ubiquitin – NMR<br />
 +
**[[2kwu]], [[2kwv]] - mDpo ι C-terminal + ubiquitin - NMR<br />
 +
**[[3ai4]] - mDpo ι/yEGFP<br />
 +
 +
*DNA polymerase kappa
 +
 +
**[[1t94]] - hDpo κ<br />
 +
**[[3in5]] - hDpo κ + DNA<br />
 +
**[[2w7o]], [[2w7p]], [[2oh2]], [[3pzp]] - hDpo κ + DNA + nucleotide<br />
 +
**[[2lsi]] - hDpo κ peptide + hRev1<br />
 +
**[[2lsk]] - mDpo κ + DNA repair protein Rev1<br />
 +
 +
*DNA polymerase mu
 +
**[[2htf]], [[2dun]] - hDpo μ BRCT domain – NMR<br />
**[[2htf]], [[2dun]] - hDpo μ BRCT domain – NMR<br />
**[[2ihm]] - mDpo μ catalytic domain + DNA – mouse<br />
**[[2ihm]] - mDpo μ catalytic domain + DNA – mouse<br />
-
**[[1rpl]], [[2bpc]], [[1bpe]], [[1bpb]], [[1bpd]], [[3uxn]] - rDpo β – rat<br />
+
 
-
**[[2van]], [[1jn3]], [[3uxo]], [[3v7l]] - rDpo β (mutant)<br />
+
*DNA polymerase nu
-
**[[1dk2]], [[1dk3]], [[1bno]], [[1bnp]] - rDpo β N-terminal – NMR<br />
+
 
-
**[[1nom]] - rDpo β C-terminal<br />
+
**[[4xvi]], [[4xvk]], [[4xvl]], [[4xvm]] – hDpo ν catalytic domain + DNA<br />
-
**[[1huo]], [[1huz]], [[3v7j]] - rDpo β + DNA<br />
+
 
-
**[[3uxp]], [[3v72]], [[3v7k]] - rDpo β (mutant) + DNA<br />
+
*DNA polymerase chi
-
**[[1bpe]] - rDpo β + nucleotide<br />
+
 
-
**[[2bpf]], [[2bpg]] - rDpo β + DNA + nucleotide<br />
+
-
**[[2w9m]] – Dpo X – ''Deinococcus radiodurans''<br />
+
-
**[[3au2]] – TtDpo β + GTP – ''Thermus thermophilus''<br />
+
-
**[[3b0x]], [[3b0y]] – TtDpo β (mutant) + GTP<br />
+
-
**[[3au6]], [[3auo]] – TtDpo β + GTP + DNA<br />
+
**[[2m2t]] – AsfvDpo X – African swine fever virus – NMR<br />
**[[2m2t]] – AsfvDpo X – African swine fever virus – NMR<br />
**[[2m2u]], [[2m2v]] – AsfvDpo X + nucleotide – NMR<br />
**[[2m2u]], [[2m2v]] – AsfvDpo X + nucleotide – NMR<br />
**[[2m2w]] – AsfvDpo X + nucleotide + DNA – NMR<br />
**[[2m2w]] – AsfvDpo X + nucleotide + DNA – NMR<br />
 +
**[[2w9m]] – Dpo X – ''Deinococcus radiodurans''<br />
-
*''Terminal deoxynucleotidyl transferase''
+
*DNA polymerase from yeast
 +
 
 +
**[[3oiq]] - yDpo α + cell division control protein 13 <br />
 +
**[[3flo]], [[3lgb]] - yDpo α subunits A,B<br />
 +
**[[4b08]], [[4fvm]] - yDpo α subunit A<br />
 +
**[[4fxd]], [[4fyd]] - yDpo α subunit A + RNA + DNA<br />
 +
**[[3iay]] - yDpo δ catalytic subunit + DNA<br />
 +
**[[3oha]], [[3ohb]], [[3mfh]] - yDpo ε (mutant) + DNA<br />
 +
**[[3mfi]], [[4m8o]] - yDpo ε (mutant) + DNA + nucleotide <br />
 +
**[[2r8j]], [[2r8k]], [[4ptf]] - yDpo ε catalytic domain + DNA + nucleotide <br />
 +
**[[2xgp]], [[2xgq]], [[2wtf]] - yDpo ε + DNA<br />
 +
**[[1jih]] – yDpo η catalytic domain<br />
 +
**[[3bjy]], [[2aq4]] – yRev1 catalytic domain + DNA + nucleotide<br />
 +
 
 +
*DNA polymerase Rev1
 +
 
 +
**[[3gqc ]]– hRev1 + DNA + nucleotide<br />
 +
**[[2ebw]] – hRev1 BRCT domain – NMR<br />
 +
**[[3bjy]], [[2aq4]] – yRev1 catalytic domain + DNA + nucleotide<br />
 +
**[[2lsi]] - hDpo κ peptide + hRev1<br />
 +
**[[4fjo]], [[4gk5]] - hDpo κ + hDpo ζ catalytic subunit + Rev1 + MAD2B<br />
 +
**[[2lsj]], [[2lsi]] - hDpo η + Rev1<br />
 +
**[[2lsk]] - mDpo κ + Rev1<br />
 +
 
 +
Terminal deoxynucleotidyl transferase
**[[2coe]] – TdT BRCT domain – NMR<br />
**[[2coe]] – TdT BRCT domain – NMR<br />
**[[1jms]] – mTdT catalytic domain + Mg <br / >
**[[1jms]] – mTdT catalytic domain + Mg <br / >
-
*''Terminal deoxynucleotidyl transferase binary complex''
+
Terminal deoxynucleotidyl transferase binary complex
**[[4iqt]], [[4iqu]], [[4iqv]], [[4iqw]] – mTdT catalytic domain + inhibitor <br / >
**[[4iqt]], [[4iqu]], [[4iqv]], [[4iqw]] – mTdT catalytic domain + inhibitor <br / >
Line 219: Line 354:
**[[4i2a]] – mTdT catalytic domain + UMP derivative + Mg <br / >
**[[4i2a]] – mTdT catalytic domain + UMP derivative + Mg <br / >
-
*''Terminal deoxynucleotidyl transferase ternary complex with DNA''
+
Terminal deoxynucleotidyl transferase ternary complex with DNA
**[[4i2e]] – mTdT catalytic domain + AMPCPP + Co + DNA <br / >
**[[4i2e]] – mTdT catalytic domain + AMPCPP + Co + DNA <br / >
Line 227: Line 362:
**[[4i28]], [[4i2f]] – mTdT catalytic domain + Mg + Zn + DNA<br / >
**[[4i28]], [[4i2f]] – mTdT catalytic domain + Mg + Zn + DNA<br / >
**[[4i2g]] – mTdT catalytic domain + Mg + Co + DNA<br / >
**[[4i2g]] – mTdT catalytic domain + Mg + Co + DNA<br / >
- 
-
*Family Y
 
- 
-
**[[2i5o]] - hDpo η ubiquitin-binding zinc finger - NMR<br />
 
-
**[[3si8]] - hDpo η + DNA<br />
 
-
**[[3abd]], [[3abe]] - hDpo ξ catalytic subunit Rev3 + mitotic spindle assembly checkpoint protein Rev7<br />
 
-
**[[3gqc]] – hRev1 + DNA + nucleotide<br />
 
-
**[[2ebw]] – hRev1 BRCT domain – NMR<br />
 
-
**[[3bjy]], [[2aq4]] – yRev1 catalytic domain + DNA + nucleotide<br />
 
-
**[[3q8r]], [[3q8s]], [[3h4b]], [[3h4d]], [[3gv5]], [[3gv7]], [[3gv8]], [[3epg]], [[3epi]], [[2fll]], [[2fln]], [[2flp]], [[2dpi]], [[2dpj]], [[2alz]], [[1zet]], [[1t3n]], [[4ebc]], [[4ebd]], [[4ebe]], [[4fs1]], [[4fs2]], [[4eyh]], [[4eyi]] - hDpo τ + DNA + nucleotide<br />
 
-
**[[3ngd]], [[3osn]], [[3h40]] - hDpo τ catalytic fragment + DNA<br />
 
-
**[[2ktf]] - hDpo τ + ubiquitin<br />
 
-
**[[2l0f]], [[2l0g]] - hDpo τ + ubiquitin – NMR<br />
 
-
**[[2khu]] - hDpo ι ubiquitin binding motif – NMR<br />
 
-
**[[2khw]] - hDpo ι ubiquitin binding motif + ubiquitin – NMR<br />
 
-
**[[3g6v]], [[3g6x]], [[3g6y]] - hDpo ι + DNA<br />
 
-
**[[1t94]] - hDpo κ<br />
 
-
**[[3in5]] - hDpo κ + DNA<br />
 
-
**[[2w7o]], [[2w7p]], [[2oh2]], [[3pzp]] - hDpo κ + DNA + nucleotide<br />
 
-
**[[2lsi]] - hDpo κ peptide + hREV1<br />
 
-
**[[4fjo]] - hDpo κ + DNA repair protein REV1 + MAD2B<br />
 
-
**[[4gk0]], [[4gk5]], [[3vu7]], [[4ext]] - hDpo η + DNA repair protein REV1 + MAD2B<br />
 
-
**[[2lsj]], [[2isi]] - hDpo η + DNA repair protein REV1<br />
 
-
**[[4ecq]], [[4ecr]], [[4ecs]], [[4ect]], [[4ecu]], [[4ecv]], [[4ecw]], [[4ecx]], [[4ecy]], [[4ecz]], [[4ed0]], [[4ed1]], [[4ed2]], [[4ed3]], [[4ed6]], [[4ed7]], [[4ed8]], [[4o3n]], [[4o3o]], [[4o3p]], [[4o3q]], [[4o3r]], [[4o3s]], [[4q8e]], [[4q8f]], [[4rnm]], [[4rnn]], [[4rno]], [[4x0p]], [[4x0q]] - hDpo η + DNA + nucleotide<br />
 
-
**[[5aga]] - hDpo η + nucleotide<br />
 
-
**[[2kwu]], [[2kwv]] - mDpo τ C-terminal + ubiquitin - NMR<br />
 
-
**[[3ai4]] - mDpo τ/yEGFP<br />
 
-
**[[1jih]] – yDpo η catalytic domain<br />
 
-
**[[2lsk]] - mDpo κ + DNA repair protein REV1<br />
 
- 
-
*Prokaryotic Pol I – DNA repair
 
- 
-
**[[1s5j]] – SsDpo I<br />
 
-
**[[3eyz]] - GsDpo I (mutant) + DNA <br />
 
-
**[[3ez5]] - GsDpo I (mutant) + DNA + nucleotide <br />
 
-
**[[3pv8]], [[3px0]], [[3px4]], [[3px6]], [[4dqi]], [[4dqp]], [[4dqq]], [[4dqr]], [[4dqs]], [[4ds4]], [[4ds5]], [[4dse]], [[4dsf]], [[4e0d]], [[4ez6]], [[4ez9]], [[4f2r]], [[4f2s]], [[4f3o]], [[4f4k]], [[4f8r]] - GkDpo I (mutant) + DNA – ''Geobacillus kaustophilus''
 
- 
-
*Prokaryotic Pol II – DNA repair
 
- 
-
**[[3o59]] - PhDpo II large subunit - ''Pyrococcus horikoshii''<br />
 
-
**[[2kxe]] - PhDpo II small subunit<br />
 
-
**[[1qqc]] – DeDpo II<br />
 
- 
-
*Prokaryotic Pol III
 
- 
-
**[[4tr6]] - Pol III β subunit – ''Bacillus subtilis''<br />
 
-
**[[3p16]], [[3rb9]], [[4tr7]] - Pol III β subunit – ''Mycobacterrium tuberculosis''<br />
 
-
**[[4tr8]] - PaPol III β subunit – ''Pseudomonas aeruginosa''<br />
 
-
**[[4tsz]] - PaPol III β subunit + peptide<br />
 
- 
-
*Prokaryotic Pol IV
 
- 
-
**[[4ir1]], [[4ir9]], [[4irc]], [[4ird]], [[4irk]] - EcPol IV + DNA<br />
 
-
**[[4r8u]] - EcPol IV + DNA + nucleotide<br />
 
-
**[[2rdi]] - SsPol IV - ''Sulfolobus solfataricus''<br />
 
-
**[[3pr4]], [[3pr5]], [[2r8g]], [[2r8h]], [[2r8i]], [[2uvr]], [[2uvu]], [[2uvv]], [[2uvw]], - SsPol IV (mutant) + DNA + nucleotide<br />
 
-
**[[4juz]], [[4jv0]], [[4jv1]], [[4jv2]] - SsPol IV + DNA + nucleotide<br />
 
-
**[[2xc9]], [[3m9m]], [[3m9n]], [[3m9o]], [[2v4q]], [[2v4r]], [[2ago]], [[1ryr]], [[1rys]], [[2w9a]], [[2w9b]], [[2w9c]], [[3gii]], [[3gij]], [[3gik]], [[3gil]], [[3gim]], [[3qz7]], [[3qz8]], [[3pvx]], [[3pw0]], [[3pw2]], [[3pw4]], [[3pw5]], [[3pw7]], [[3raq]], [[3rax]], [[3rb0]], [[3rb3]], [[3rb4]], [[3rb6]], [[3rbd]], [[3rbe]], [[4hyk]], [[4fbt]], [[4fbu]], [[4g3i]] - SsPol IV + DNA<br />
 
-
**[[2xca]], [[2xcp]], [[3khg]], [[3khh]], [[3khl]], [[3khr]], [[2w8k]], [[2w8l]], [[2rdj]], [[2v9w]], [[2va2]], [[2va3]], [[2ia6]], [[2ibk]], [[2jef]], [[2jeg]], [[2jei]], [[2jej]], [[2imw]], [[2j6s]], [[2j6t]], [[2j6u]], [[2asd]], [[2asj]], [[2asl]], [[2atl]], [[2au0]], [[2c22]], [[2c28]], [[2c2d]], [[2c2e]], [[2c2r]], [[2agp]], [[2agq]], [[2bqr]], [[2bqu]], [[2br0]], [[2bq3]], [[1s9f]], [[1s97]], [[1s0m]], [[1s0n]], [[1s0o]], [[1s10]], [[1n48]], [[1n56]], [[1jx4]], [[1jxl]], [[3t5h]], [[3t5j]], [[3t5k]], [[3t5l]], [[3v6h]], [[3v6j]], [[3v6k]], [[4gc6]], [[4gc7]] - SsPol IV + DNA + nucleotide<br />
 
-
**[[3fds]] – SsPol IV + PCNA B + PCNA C<br />
 
-
**[[3bq2]], [[3bq0]] – SaPol IV + DNA – ''Sulfolobus acidocaldarius''<br />
 
-
**[[3bq1]], [[4f4w]], [[4f4x]], [[4f4y]], [[4f4z]], [[4f50]] - SaPol IV + DNA + nucleotide<br />
 
-
**[[4nlg]] - SaPol IV (mutant) + DNA<br />
 
-
**[[4dez]] – Pol IV – ''Mycobacterium smegmatis''
 
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:16, 20 October 2015

Template:STRUCTURE 1taq

DNA polymerase (Dpo) reads a DNA strand and catalyzes the synthesis of its complementary strand. Dpo's are divided into 7 families according to their sequence homology and 3D structure similarities. The families are:

  • Family A - replicative or repair Dpo.
  • Family B - replicative Dpo involved in processing DNA replication during cell division (includes eukaryotic Dpo α,δ,ε).
  • Family C - major replicative Dpo in bacteria (includes Dpo II, III, IV).
  • Family D - replicative. Present in archaea.
  • Family X - eukaryotic repair Dpo (includes Dpo β,λ,σ,μ and terminal deoxynucleotidyl transferase).
  • Family Y - replicative of damaged DNA (includes eukaryotic η,ι,κ).
  • Family RT - reverse transcriptase. See Reverse transcriptase.

Some Dpo terminology:
Dpo sliding clamp is made of the complex of Dpo and Proliferating Cell Nuclear Antigen (PCNA) which encircles it.
The BRCT domain in Dpo is the C-terminal domain of breast cancer susceptibility protein.
Klenow fragment is a large Dpo fragment produced upon cleavage of Dpo by subtilisin.
In the E. coli, the EcDpo III subunits β, γ, δ, δ' are named clamp loader. This complex assembles the β subunit sliding clamp unto the DNA.
Rev1 is a Dpo involved in replication over DNA lesions.
Terminal deoxynucleotidyl transferase (TdT) is a family X Dpo expressed in immature lymphoid cells. TdT adds nucleotides to exons during antibody gene recombination.
For more details see

3D Structures of DNA polymerase

Updated on 20-October-2015 

Terminal deoxynucleotidyl transferase

Terminal deoxynucleotidyl transferase binary complex

Terminal deoxynucleotidyl transferase ternary complex with DNA

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