7,8-dihydro-8-oxoguanine triphosphatase
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Function == | == Function == | ||
| - | '''7,8-dihydro-8-oxoguanine triphosphatase''' (DGTP) converts 8-oxoguanine containing deoxyribonucleoside triphosphate to the corresponding monophosphate. | + | '''7,8-dihydro-8-oxoguanine triphosphatase''' (DGTP) converts 8-oxoguanine containing deoxyribonucleoside triphosphate to the corresponding monophosphate. DGTP controls spontaneous mutagenesis caused by exogenous oxygen radicals. The ''E. coli'' DGTP is called '''MutT'''. The human DGTP is called '''MTH1'''. |
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| + | |||
| + | The 8-oxo-dGTP (oxoG) is a potentially mutagenic substrate when incorporated into DNA. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:14, 21 October 2015
| |||||||||||
3D structures of 7,8-dihydro-8-oxoguanine triphosphatase
Updated on 21-October-2015
