Acetyl-CoA synthase
From Proteopedia
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| - | '''Acetyl-CoA synthase''' (ACS) is a Fe-Ni-S containing enzyme found in archae and bacteria. ACS is divided to 4 classes | + | '''Acetyl-CoA synthase''' (ACS) is a Fe-Ni-S containing enzyme found in archae and bacteria. ACS is divided to 4 classes:<br /> |
| + | * '''ACS-I''' catalyzes the synthesis of acetyl-CoA from CoA, CO2, methyl group and 2 electrons.<br /> | ||
| + | * '''ACS-I'''I catalyzes the reverse reaction. <br /> | ||
| + | * '''ACS-III''' uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.<br /> | ||
| + | * '''ACS-IV''' catabolizes CO to CO2. <br /> | ||
| + | ACS can form a bifunctional entity with carbon monoxide dehydrogenase (CODH). | ||
| + | == Structural highlights == | ||
| + | |||
| + | ACS-I and ACS-II contain 5 subunits: α, β, γ, δ, ε. ACS-III is composed of 2 proteins: 2α+2β and γ+δ. ACS-IV is composed of α monomer. | ||
==3D structures of acetyl-CoA synthase== | ==3D structures of acetyl-CoA synthase== | ||
Revision as of 07:09, 22 October 2015
Acetyl-CoA synthase (ACS) is a Fe-Ni-S containing enzyme found in archae and bacteria. ACS is divided to 4 classes:
- ACS-I catalyzes the synthesis of acetyl-CoA from CoA, CO2, methyl group and 2 electrons.
- ACS-II catalyzes the reverse reaction.
- ACS-III uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.
- ACS-IV catabolizes CO to CO2.
ACS can form a bifunctional entity with carbon monoxide dehydrogenase (CODH).
Structural highlights
ACS-I and ACS-II contain 5 subunits: α, β, γ, δ, ε. ACS-III is composed of 2 proteins: 2α+2β and γ+δ. ACS-IV is composed of α monomer.
3D structures of acetyl-CoA synthase
Updated on 22-October-2015
