Acetyl-CoA synthase
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
to a Jmol applet. Check out the other buttons as well! | to a Jmol applet. Check out the other buttons as well! | ||
--> | --> | ||
| + | |||
| + | == Function == | ||
| + | |||
'''Acetyl-CoA synthase''' (ACS) is a Fe-Ni-S containing enzyme found in archae and bacteria. ACS is divided to 4 classes:<br /> | '''Acetyl-CoA synthase''' (ACS) is a Fe-Ni-S containing enzyme found in archae and bacteria. ACS is divided to 4 classes:<br /> | ||
* '''ACS-I''' catalyzes the synthesis of acetyl-CoA from CoA, CO2, methyl group and 2 electrons.<br /> | * '''ACS-I''' catalyzes the synthesis of acetyl-CoA from CoA, CO2, methyl group and 2 electrons.<br /> | ||
| Line 11: | Line 14: | ||
* '''ACS-III''' uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.<br /> | * '''ACS-III''' uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.<br /> | ||
* '''ACS-IV''' catabolizes CO to CO2. <br /> | * '''ACS-IV''' catabolizes CO to CO2. <br /> | ||
| - | ACS can form a bifunctional entity with carbon monoxide dehydrogenase (CODH). | + | ACS can form a bifunctional entity with carbon monoxide dehydrogenase ('''CODH/ACS'''). CODH/ACS is part of the Woods-Ljungdahl pathway of carbon fixation using CO and methyl group to produce acetyl-CoA. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 08:03, 22 October 2015
Function
Acetyl-CoA synthase (ACS) is a Fe-Ni-S containing enzyme found in archae and bacteria. ACS is divided to 4 classes:
- ACS-I catalyzes the synthesis of acetyl-CoA from CoA, CO2, methyl group and 2 electrons.
- ACS-II catalyzes the reverse reaction.
- ACS-III uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.
- ACS-IV catabolizes CO to CO2.
ACS can form a bifunctional entity with carbon monoxide dehydrogenase (CODH/ACS). CODH/ACS is part of the Woods-Ljungdahl pathway of carbon fixation using CO and methyl group to produce acetyl-CoA.
Structural highlights
ACS-I and ACS-II contain 5 subunits: α, β, γ, δ, ε. ACS-III is composed of 2 proteins: 2α+2β and γ+δ. ACS-IV is composed of α monomer.
3D structures of acetyl-CoA synthase
Updated on 22-October-2015
