Adenosine A2A receptor
From Proteopedia
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| + | {{STRUCTURE_2ydo| PDB=2ydo | SIZE=350| SCENE=|right|CAPTION= Human A2AR (mutant) complex with adenosine [[2ydo]] }} | ||
| - | + | == Function == | |
| - | '''Adenosine A2A receptor''' (A2AR) is one of the G protein-coupled receptors. A2AR is responsible for regulating myocardial blood flow. For details see [[G protein-coupled receptor]]. | + | '''Adenosine A2A receptor''' (A2AR) is one of the G protein-coupled receptors. |
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| + | == Disease == | ||
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| + | A2AR antagonists are being tested in the treatment of Alzheimer's Disease. | ||
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| + | == Relevance == | ||
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| + | A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. | ||
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| + | == Structural highlights == | ||
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| + | Like other G proteins, A2AR has 7 transmembrane helices. A2AR posses a ligand-binding cavity. | ||
== 3D Structures of adenosine A2A receptor == | == 3D Structures of adenosine A2A receptor == | ||
Revision as of 11:56, 27 October 2015
Contents |
Function
Adenosine A2A receptor (A2AR) is one of the G protein-coupled receptors.
Disease
A2AR antagonists are being tested in the treatment of Alzheimer's Disease.
Relevance
A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see G protein-coupled receptor.
Structural highlights
Like other G proteins, A2AR has 7 transmembrane helices. A2AR posses a ligand-binding cavity.
3D Structures of adenosine A2A receptor
Updated on 27-October-2015
3eml – hA2AR/lysozyme + antagonist – human
3qak – hA2AR/lysozyme + agonist
2ydo – hA2AR (mutant) + adenosine
2ydv – hA2AR (mutant) + agonist
3pwh, 3rey, 3rfm, 3uza, 3uzc – hA2AR (mutant) + antagonist
3vg9, 3vga – hA2AR (mutant) + antibody
4eiy – hA2AR/cytochrome b562 + antagonist
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Nina Clavio, Joel L. Sussman
