Alanine racemase
From Proteopedia
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<StructureSection load='1l6g' size='350' side='right' caption='Structure of alanine racemase dimer complex with phosphopyridoxyl-alanine (PDB entry [[1l6g]])' scene=''> | <StructureSection load='1l6g' size='350' side='right' caption='Structure of alanine racemase dimer complex with phosphopyridoxyl-alanine (PDB entry [[1l6g]])' scene=''> | ||
| - | '''Alanine racemase''' (AR) catalyzes the racemization of L-alanine to D-alanine. AR uses pyridoxal-5’-phosphate (PLP) as a cofactor. PLP binds to a lysine residue of AR. AR participates in alanine and aspartate metabolism. The antibiotic D-cycloserine is an effective inhibitor of AR. | + | == Function == |
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| + | '''Alanine racemase''' (AR) catalyzes the racemization of L-alanine to D-alanine. AR uses pyridoxal-5’-phosphate (PLP) as a cofactor. PLP binds to a lysine residue of AR. AR participates in alanine and aspartate metabolism. | ||
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| + | == Disease == | ||
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| + | The antibiotic D-cycloserine is an effective inhibitor of AR. | ||
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| + | == Relevance == | ||
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| + | The D-alanine produced by AR is used for peptidoglycan biosynthesis. Peptidoglycans are found in cell walls of bacteria hence AR inhibitors are tested as antimicrobial drugs. | ||
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| + | == Structural highlights == | ||
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| + | AR uses 2 catalytic bases for the reaction: Lys and Tyr. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:36, 28 October 2015
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3D Structures of alanine racemase
Updated on 28-October-2015
