Acetylcholine binding protein
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
== Structural highlights == | == Structural highlights == | ||
| - | The crystal structures of the ''Lymnaea stagnalis'' and the ''Aplysia californica'' <scene name='39/399849/Cv/4'>AChBP homopentamer</scene> indeed provides a valuable model for identifying the nature of the ligand-binding domains and of the subunit interfaces of the nAChR. Furthermore, crystal structures of complexes of AChBP with various agonists and antagonists have provided detailed insight into the neurotransmitter binding site of nAChRs. <scene name='39/399849/Cv/5'>The binding site of AChBP is located at the interface of neighboring subunits</scene>. Chain A is in cyan, chain B is in salmon, ACh is in yellow. | + | The crystal structures of the ''Lymnaea stagnalis'' and the ''Aplysia californica'' <scene name='39/399849/Cv/4'>AChBP homopentamer</scene> indeed provides a valuable model for identifying the nature of the ligand-binding domains and of the subunit interfaces of the nAChR. Furthermore, crystal structures of complexes of AChBP with various agonists and antagonists have provided detailed insight into the neurotransmitter binding site of nAChRs. <scene name='39/399849/Cv/5'>The binding site of AChBP is located at the interface of neighboring subunits</scene>. Chain A is in cyan, chain B is in salmon, ACh is in yellow. <ref>PMID:11357121</ref> <ref>PMID:11683996</ref> <ref>PMID:24637639</ref> |
== Relevance == | == Relevance == | ||
| Line 103: | Line 103: | ||
For additional information, see: [[Alzheimer's Disease]] | For additional information, see: [[Alzheimer's Disease]] | ||
<br /> | <br /> | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:50, 8 November 2015
| |||||||||||
3D Structures of Acetylcholine binding protein
Updated on 08-November-2015
Additional Resources
For additional information, see: Alzheimer's Disease
References
- ↑ Smit AB, Syed NI, Schaap D, van Minnen J, Klumperman J, Kits KS, Lodder H, van der Schors RC, van Elk R, Sorgedrager B, Brejc K, Sixma TK, Geraerts WP. A glia-derived acetylcholine-binding protein that modulates synaptic transmission. Nature. 2001 May 17;411(6835):261-8. PMID:11357121 doi:10.1038/35077000
- ↑ Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996
- ↑ Olsen JA, Balle T, Gajhede M, Ahring PK, Kastrup JS. Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors. PLoS One. 2014 Mar 17;9(3):e91232. doi: 10.1371/journal.pone.0091232. eCollection, 2014. PMID:24637639 doi:http://dx.doi.org/10.1371/journal.pone.0091232
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, David Canner
