Barnase
From Proteopedia
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{{STRUCTURE_1bni| PDB=1bni | SIZE=400| SCENE=Barnase/Cv/1 |right|CAPTION='3 monomers of barnase [[1bni]]' }} | {{STRUCTURE_1bni| PDB=1bni | SIZE=400| SCENE=Barnase/Cv/1 |right|CAPTION='3 monomers of barnase [[1bni]]' }} | ||
| + | <StructureSection load='1brn' size='450' side='right' scene= caption='Lymnaea acetylcholine-binding protein pentamer complex with acetylcholine (PDB code 3wip)'> | ||
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| + | == Function == | ||
'''Barnase''' (BA, BActerial RiboNucleASE) is a bacterial ribonuclease synthesized and secreted by the bacterium ''Bacillus amyloliquefaciens''. The inhibitor barstar (BST) binds to it very tightly and prevents it from digestion of the cell’s RNA. | '''Barnase''' (BA, BActerial RiboNucleASE) is a bacterial ribonuclease synthesized and secreted by the bacterium ''Bacillus amyloliquefaciens''. The inhibitor barstar (BST) binds to it very tightly and prevents it from digestion of the cell’s RNA. | ||
| - | + | == Relevance == | |
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| + | BA structure was used extensively for studying protein folding. | ||
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| + | == Structural highlights == | ||
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| + | BA hydrolyzes RNA at GpN sites where the positively charge Lys and Arg coordinate the RNA phosphate group. | ||
== 3D Structures of Barnase == | == 3D Structures of Barnase == | ||
Revision as of 08:57, 9 November 2015
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