Beta-lactamase
From Proteopedia
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'''Beta-lactamase''' (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. '''Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases.''' '''Carbapenemase''' (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. '''Extended-spectrum Blac class A''' (ESBL) hydrolyze penicillins but not cephalosporins. | '''Beta-lactamase''' (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. '''Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases.''' '''Carbapenemase''' (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. '''Extended-spectrum Blac class A''' (ESBL) hydrolyze penicillins but not cephalosporins. | ||
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| + | Blac makes some bacteria resistant to antibiotics like penicillin, cephamycin and carbapenems. | ||
== 3D Structures of Beta-lactamase == | == 3D Structures of Beta-lactamase == | ||
Revision as of 10:41, 10 November 2015
Beta-lactamase (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases. Carbapenemase (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. Extended-spectrum Blac class A (ESBL) hydrolyze penicillins but not cephalosporins.
Relevance
Blac makes some bacteria resistant to antibiotics like penicillin, cephamycin and carbapenems.
3D Structures of Beta-lactamase
Updated on 10-November-2015
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Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman
