Beta-phosphoglucomutase

Function

Beta-phosphoglucomutase (BPGM) catalyzes the conversion of β-D-glucose 1-phosphate to β-D-glucose 6-phosphate. Mg+2 ion is the cofactor of the reaction and BPGM activation is achieved by Asp8 phosphorylation (D8P). α-D-galactose-1-phosphate is an inhibitor of BPGM. BPGM participates in sugar and starch metabolism.

Disease

Relevance

Structural highlights

BPGM structure shows the enzyme having 2 domains. A helical cap domain and an α/β core domain. The active site is located in the core domain and contains a phosphorylated Asp residue and the octahedral coordinated Mg+2 ion.