Beta-adrenergic receptor kinase
From Proteopedia
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<StructureSection load='3uzt' size='340' side='right' caption='Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code [[3uzt]])' scene=''> | <StructureSection load='3uzt' size='340' side='right' caption='Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code [[3uzt]])' scene=''> | ||
| - | '''Beta adrenergic receptor kinase''' (BARK) is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adregenic receptor (BAR) when it is occupied by the agonist thus causing its desensitization. BARK belongs to the family of G protein-coupled receptor kinase (GRK). | + | '''Beta adrenergic receptor kinase''' (BARK) is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adregenic receptor (BAR) when it is occupied by the agonist thus causing its desensitization. BARK belongs to the family of G protein-coupled receptor kinase (GRK). <ref>PMID:2871555</ref> |
== 3D Structures of β adrenergic receptor kinase == | == 3D Structures of β adrenergic receptor kinase == | ||
Revision as of 13:27, 15 November 2015
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References
- ↑ Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801. PMID:2871555
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