Calcineurin
From Proteopedia
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[1tco]] – CN + FK-506-binding protein + Ca + Fe + Zn – bovine<br /> | + | [[1tco]] – CN subunit A, B + FK-506-binding protein + Ca + Fe + Zn – bovine<br /> |
| - | [[1aui]] - hCN + Ca + Fe + Zn – human<br /> | + | [[1aui]] - hCN subunit A, B + Ca + Fe + Zn – human<br /> |
| - | [[4il1]] – CN + Ca – rat<br /> | + | [[4il1]] – CN subunit A, B/calmodulin + Ca – rat<br /> |
[[1m63]], [[1mf8]] - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn<br /> | [[1m63]], [[1mf8]] - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn<br /> | ||
| - | [[2p6b]] - hCN + PVIVIT peptide + Ca + Fe + Zn<br /> | + | [[2p6b]] - hCN subunit A, B + PVIVIT peptide + Ca + Fe + Zn<br /> |
| - | [[3ll8]] - hCN + AKAP79 peptide + Ca + Fe + Zn<br /> | + | [[3ll8]] - hCN subunit A, B + AKAP79 peptide + Ca + Fe + Zn<br /> |
| - | [[2jog]] - hCN | + | [[2jog]] - hCN subunit A + NFAT peptide<br /> |
| - | [[ | + | [[2w73]], [[2jzi]] - hCN subunit A calmodulin-binding domain + calmodulin + Ca<br /> |
| - | [[ | + | |
[[4f0z]] – hCN subunit B + African swine protein virus + Ca<br /> | [[4f0z]] – hCN subunit B + African swine protein virus + Ca<br /> | ||
Revision as of 10:50, 16 November 2015
Contents |
Function
Calcineurin (CN) is a eukaryotic calcium-dependent serine/threonine protein phosphatase 2B which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways. For more details see Group:MUZIC:Calcineurin.
Relevance
CN inhibitors are used as drugs in cases of rheumatic diseases, schizophrenia and diabetes. It is inhibited by immunosuppressant drugs like cyclosporine.
Structural highlights
It contains a calmodulin-binding catalytic subunit A and a Ca+2-binding regulatory subunit B. There are 2 metal ions in CN active site.
3D structures of calcineurin
Updated on 16-November-2015
1tco – CN subunit A, B + FK-506-binding protein + Ca + Fe + Zn – bovine
1aui - hCN subunit A, B + Ca + Fe + Zn – human
4il1 – CN subunit A, B/calmodulin + Ca – rat
1m63, 1mf8 - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn
2p6b - hCN subunit A, B + PVIVIT peptide + Ca + Fe + Zn
3ll8 - hCN subunit A, B + AKAP79 peptide + Ca + Fe + Zn
2jog - hCN subunit A + NFAT peptide
2w73, 2jzi - hCN subunit A calmodulin-binding domain + calmodulin + Ca
4f0z – hCN subunit B + African swine protein virus + Ca
