Calcineurin

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<StructureSection load='1aui' size='450' side='right' scene='48/489261/Cv/1' caption='Human calcineurin regulatory subunit B (green) and catalytic subunit A (grey) complex with Ca+2 (green), Fe +3 (red) and Zn+2 (grey) ions, [[1aui]]'>
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<StructureSection load='1aui' size='450' side='right' scene='48/489261/Cv/1' caption='Human calcineurin regulatory subunit B (green) and catalytic subunit A (grey) complex with Ca+2 (green), Fe +3 (orange) and Zn+2 (grey) ions, [[1aui]]'>
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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It contains a <scene name='48/489261/Cv/2'>calmodulin-binding catalytic subunit A</scene> and a <scene name='48/489261/Cv/3'>Ca+2-binding regulatory subunit B</scene>. There are <scene name='48/489261/Cv/4'>2 metal ions in CN active site</scene>.<ref>PMID:8524402</ref>
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It contains a <scene name='48/489261/Cv/2'>calmodulin-binding catalytic subunit A</scene> and a <scene name='48/489261/Cv/3'>Ca+2-binding regulatory subunit B</scene>. There are <scene name='48/489261/Cv/4'>2 metal ions in CN active site</scene> (molecules of water are shown as red spheres).<ref>PMID:8524402</ref>
</StructureSection>
</StructureSection>
==3D structures of calcineurin==
==3D structures of calcineurin==

Revision as of 14:23, 17 November 2015

Human calcineurin regulatory subunit B (green) and catalytic subunit A (grey) complex with Ca+2 (green), Fe +3 (orange) and Zn+2 (grey) ions, 1aui

Drag the structure with the mouse to rotate

3D structures of calcineurin

Updated on 17-November-2015

1tco – CN subunit A, B + FK-506-binding protein + Ca + Fe + Zn – bovine
1aui - hCN subunit A, B + Ca + Fe + Zn – human
4il1 – CN subunit A, B/calmodulin + Ca – rat
1m63, 1mf8 - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn
2p6b - hCN subunit A, B + PVIVIT peptide + Ca + Fe + Zn
3ll8 - hCN subunit A, B + AKAP79 peptide + Ca + Fe + Zn
2jog - hCN subunit A + NFAT peptide
2w73, 2jzi - hCN subunit A calmodulin-binding domain + calmodulin + Ca
4f0z – hCN subunit B + African swine protein virus + Ca

References

  1. ↑ Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, et al.. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature. 1995 Dec 7;378(6557):641-4. PMID:8524402 doi:http://dx.doi.org/10.1038/378641a0

See Group:MUZIC:Calcineurin.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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