Carbamoyl phosphate synthetase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
| - | CPS I and II are composed of 2 subunits. The large subunit contain active sites which bind nucleotides and other effectors. The small subunit catalyzes the hydrolysis of glutamine to glutamate and NH3. The <scene name='49/493669/Cv/2'>small subunit active site contains an active Cys residue</scene>. CPS I contains a methylglyoxal synthetase (MGS) domain which binds ornithine. | + | CPS I and II are composed of 2 subunits. The large subunit contain active sites which bind nucleotides and other effectors. The small subunit catalyzes the hydrolysis of glutamine to glutamate and NH3. The <scene name='49/493669/Cv/2'>small subunit active site contains an active Cys residue</scene>.<ref>PMID:9636022</ref> CPS I contains a methylglyoxal synthetase (MGS) domain which binds ornithine. |
</StructureSection> | </StructureSection> | ||
==3D structures of carbamoyl phosphate synthetase== | ==3D structures of carbamoyl phosphate synthetase== | ||
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[[1kee]] - EcCPS + phosphate + ornithine + acivicin + ADP<BR /> | [[1kee]] - EcCPS + phosphate + ornithine + acivicin + ADP<BR /> | ||
[[1t36]] - EcCPS (mutant) + phosphate + ornithine + UMP + ADP<BR /> | [[1t36]] - EcCPS (mutant) + phosphate + ornithine + UMP + ADP<BR /> | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:22, 19 November 2015
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3D structures of carbamoyl phosphate synthetase
Updated on 19-November-2015
2yvq – CPS I MGS domain - human
1jdb - EcCPS + phosphate + glutamine + ADP – Escherichia coli
1a9x, 1cs0 - EcCPS + phosphate + ornithine + ADP
1c30, 1m6v - EcCPS (mutant) + phosphate + ornithine + ADP
1bxr - EcCPS + ornithine + AMPPNP
1ce8 - EcCPS + phosphate + ornithine + inosinic acid + ADP
1c3o - EcCPS (mutant) + phosphate + ornithine + glutamine + ADP
1kee - EcCPS + phosphate + ornithine + acivicin + ADP
1t36 - EcCPS (mutant) + phosphate + ornithine + UMP + ADP
References
- ↑ Thoden JB, Miran SG, Phillips JC, Howard AJ, Raushel FM, Holden HM. Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis. Biochemistry. 1998 Jun 23;37(25):8825-31. PMID:9636022 doi:http://dx.doi.org/10.1021/bi9807761
