Catabolite gene activator protein
From Proteopedia
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'''Catabolite gene activator protein''' (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. Two cAMP molecules bind to the dimeric CAP. When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes. | '''Catabolite gene activator protein''' (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. Two cAMP molecules bind to the dimeric CAP. When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes. | ||
| - | *<scene name='54/543372/Cv/2'>Catabolite gene activator protein complex with cAMP and DNA</scene> ([[1o3r]]). | + | *<scene name='54/543372/Cv/2'>Catabolite gene activator protein complex with cAMP and DNA</scene> ([[1o3r]]).<ref>PMID:2982847</ref> |
</StructureSection> | </StructureSection> | ||
== 3D Structures of catabolite gene activator protein == | == 3D Structures of catabolite gene activator protein == | ||
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**[[3iyd]] – EcCAP + cAMP + DNA + DNA-directed RNA polymerase α, β, ω subunits + RNA polymerase σ factor – Cryo EM<br /> | **[[3iyd]] – EcCAP + cAMP + DNA + DNA-directed RNA polymerase α, β, ω subunits + RNA polymerase σ factor – Cryo EM<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:30, 22 November 2015
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3D Structures of catabolite gene activator protein
Updated on 22-November-2015
References
- ↑ Aiba H. Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein. J Biol Chem. 1985 Mar 10;260(5):3063-70. PMID:2982847
