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1a9l
From Proteopedia
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{{Structure | {{Structure | ||
|PDB= 1a9l |SIZE=350|CAPTION= <scene name='initialview01'>1a9l</scene> | |PDB= 1a9l |SIZE=350|CAPTION= <scene name='initialview01'>1a9l</scene> | ||
| - | |SITE= <scene name='pdbsite=NUL:Enzymatic+Cleavage+Occurs+3 | + | |SITE= <scene name='pdbsite=NUL:Enzymatic+Cleavage+Occurs+3'+To+These+Residues'>NUL</scene> |
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2a9l|2A9L]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9l OCA], [http://www.ebi.ac.uk/pdbsum/1a9l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a9l RCSB]</span> | ||
}} | }} | ||
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[[Category: nmr]] | [[Category: nmr]] | ||
[[Category: pre-trna splicing]] | [[Category: pre-trna splicing]] | ||
| - | + | [[Category: rna structure,ribonucleic acid]] | |
| - | [[Category: rna structure]] | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:36:07 2008'' |
Revision as of 15:36, 30 March 2008
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| Sites: | |||||||
| Ligands: | , , , | ||||||
| Related: | 2A9L
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, NMR, 12 STRUCTURES
Overview
The structure of the bulge-helix-bulge motif that constitutes the intron/exon splice site in H. volcanii pre-tRNATrp has been determined by NMR spectroscopy. The conformations of the two 3 nt bulges, where the pre-tRNA is cleaved, are stabilized by stacking interactions between bulge nucleotides and bases in the adjacent Watson-Crick helices and by a network of backbone hydrogen bonds. Both bulges are presented on the same minor groove face of the central 4 bp helix, and the overall structure has approximate two-fold symmetry, which makes it well-suited for attack by archaeal splicing endonucleases, which are symmetric dimers.
About this Structure
1A9L is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:9660971
Page seeded by OCA on Sun Mar 30 18:36:07 2008
