4z92
From Proteopedia
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| - | ''' | + | ==crystal structure of parechovirus-1 virion== |
| - | + | <StructureSection load='4z92' size='340' side='right' caption='[[4z92]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4z92]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z92 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z92 OCA], [http://pdbe.org/4z92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z92 RCSB], [http://www.ebi.ac.uk/pdbsum/4z92 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/POLG_HPE1H POLG_HPE1H]] Capsid proteins VP0, VP2, VP3 form a closed capsid enclosing the viral positive strand RNA genome. Capsid proteins interact with host alpha-V/beta-3 integrin heterodimer to provide virion attachment target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:11160695</ref> Protein 2A: Is not a protease. Protein 2B: Affects membrane integrity and cause an increase in membrane permeability. Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity). Protein 3A, via its hydrophobic domain, serves as membrane anchor. Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease (By similarity). RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.[PROSITE-ProRule:PRU00539] |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Kalynych, S]] | [[Category: Kalynych, S]] | ||
[[Category: Palkova, L]] | [[Category: Palkova, L]] | ||
| + | [[Category: Plevka, P]] | ||
| + | [[Category: Parechovirus]] | ||
| + | [[Category: Pathogen]] | ||
| + | [[Category: Picornavirus]] | ||
| + | [[Category: Virion]] | ||
| + | [[Category: Virus]] | ||
Revision as of 18:57, 1 December 2015
crystal structure of parechovirus-1 virion
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Categories: Kalynych, S | Palkova, L | Plevka, P | Parechovirus | Pathogen | Picornavirus | Virion | Virus
