DNA Polymerase in Thermococcus gorgonarius

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Function

DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. The binding of cytosine to guanine and adenine to thymine help make the replication on DNA polymerase easier, but an extra step of proofreading and cutting out mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. (http://www.rcsb.org/pdb/101/motm.do?momID=3)

Disease

http://tools.niehs.nih.gov/polg/

Relevance

Structural highlights

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