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5d7n

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'''Unreleased structure'''
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==Crystal structure of human Sirt3 at an improved resolution==
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<StructureSection load='5d7n' size='340' side='right' caption='[[5d7n]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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The entry 5d7n is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5d7n]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7N FirstGlance]. <br>
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Authors: Rumpf, T., Gerhardt, S., Einsle, O., Jung, M.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7n OCA], [http://pdbe.org/5d7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7n RCSB], [http://www.ebi.ac.uk/pdbsum/5d7n PDBsum]</span></td></tr>
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Description:
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Rumpf, T]]
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[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Einsle, O]]
[[Category: Gerhardt, S]]
[[Category: Gerhardt, S]]
[[Category: Jung, M]]
[[Category: Jung, M]]
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[[Category: Einsle, O]]
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[[Category: Rumpf, T]]
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[[Category: Deacylase]]
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[[Category: Hydrolase]]
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[[Category: Sirtuin 3]]

Revision as of 16:17, 2 December 2015

Crystal structure of human Sirt3 at an improved resolution

5d7n, resolution 1.83Å

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