7,8-dihydro-8-oxoguanine triphosphatase
From Proteopedia
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== Function == | == Function == | ||
| - | '''7,8-dihydro-8-oxoguanine triphosphatase''' (DGTP) converts 8-oxoguanine containing deoxyribonucleoside triphosphate to the corresponding monophosphate. DGTP controls spontaneous mutagenesis caused by exogenous oxygen radicals. The ''E. coli'' DGTP is called '''MutT'''. The human DGTP is called '''MTH1'''. | + | '''7,8-dihydro-8-oxoguanine triphosphatase''' (DGTP) converts 8-oxoguanine containing deoxyribonucleoside triphosphate to the corresponding monophosphate. DGTP controls spontaneous mutagenesis caused by exogenous oxygen radicals. The ''E. coli'' DGTP is called '''MutT'''. The human DGTP is called '''MTH1'''.<ref>PMID:19864691</ref> |
== Relevance == | == Relevance == | ||
Revision as of 07:39, 6 December 2015
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3D structures of 7,8-dihydro-8-oxoguanine triphosphatase
Updated on 06-December-2015
References
- ↑ Nakamura T, Meshitsuka S, Kitagawa S, Abe N, Yamada J, Ishino T, Nakano H, Tsuzuki T, Doi T, Kobayashi Y, Fujii S, Sekiguchi M, Yamagata Y. Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. J Biol Chem. 2010 Jan 1;285(1):444-52. Epub 2009 Oct 28. PMID:19864691 doi:10.1074/jbc.M109.066373
